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Integrative Analysis of Breast Cancer Cells Reveals an Epithelial-Mesenchymal Transition Role in Adaptation to Acidic Microenvironment

Early ducts of breast tumors are unequivocally acidic. High rates of glycolysis combined with poor perfusion lead to a congestion of acidic metabolites in the tumor microenvironment, and pre-malignant cells must adapt to this acidosis to thrive. Adaptation to acidosis selects cancer cells that can t...

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Detalles Bibliográficos
Autores principales:	Sadeghi, Mehdi, Ordway, Bryce, Rafiei, Ilyia, Borad, Punit, Fang, Bin, Koomen, John L., Zhang, Chaomei, Yoder, Sean, Johnson, Joseph, Damaghi, Mehdi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076123/ https://www.ncbi.nlm.nih.gov/pubmed/32211331 http://dx.doi.org/10.3389/fonc.2020.00304

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