E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation

The NAD-dependent histone deacetylase sirtuin 2 (SIRT2) plays critical roles in mitosis and cell cycle progression and recently was shown to suppress tumor growth and to be downregulated in several types of cancers. However, the underlying mechanism of SIRT2 downregulation remains unknown. In this s...

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Detalles Bibliográficos
Autores principales: Liu, Liu, Yu, Le, Zeng, Cheng, Long, Hua, Duan, Guangjie, Yin, Guobing, Dai, Xiaotian, Lin, Zhenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076256/
https://www.ncbi.nlm.nih.gov/pubmed/31932479
http://dx.doi.org/10.1128/MCB.00257-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076256/
https://www.ncbi.nlm.nih.gov/pubmed/31932479
http://dx.doi.org/10.1128/MCB.00257-19

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