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Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives

Triterpenes from the outer bark of birch have many beneficial biological and pharmacological activities. In particular, its wound healing efficacy is of paramount importance. Apart from that, particles of a birch bark dry extract aggregate into a three dimensional network when they are dispersed in...

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Autores principales: Ghaffar, Kashif Ahmad, Daniels, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076353/
https://www.ncbi.nlm.nih.gov/pubmed/32098195
http://dx.doi.org/10.3390/pharmaceutics12020184
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author Ghaffar, Kashif Ahmad
Daniels, Rolf
author_facet Ghaffar, Kashif Ahmad
Daniels, Rolf
author_sort Ghaffar, Kashif Ahmad
collection PubMed
description Triterpenes from the outer bark of birch have many beneficial biological and pharmacological activities. In particular, its wound healing efficacy is of paramount importance. Apart from that, particles of a birch bark dry extract aggregate into a three dimensional network when they are dispersed in lipids yielding a semi-solid oleogel. However, gel formation requires high amounts of the extract, which then acts at once as the active ingredient and the gelling agent. Infrared spectra of the respective mixtures proved that hydrogen bonds play a crucial role in the formation of the gel network. Dicarboxylic acids had almost no effect on gel strength. Monoalcohols increased the firmness of the oleogel with a decreasing effect from methanol > ethanol > butanol > octanol. All tested terminal diols increased the gel strength whereas vicinal diols affected the gel strength negatively. The effect was highly dependent on their concentration. The different effects of the diols are linked to their structure and polarity. The most pronounced enhancement of gelation was found for 1,6-hexanediol, which reduced the amount of triterpene extract (TE), which is necessary for the formation of an oleogel by a factor of 10.
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spelling pubmed-70763532020-03-24 Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives Ghaffar, Kashif Ahmad Daniels, Rolf Pharmaceutics Article Triterpenes from the outer bark of birch have many beneficial biological and pharmacological activities. In particular, its wound healing efficacy is of paramount importance. Apart from that, particles of a birch bark dry extract aggregate into a three dimensional network when they are dispersed in lipids yielding a semi-solid oleogel. However, gel formation requires high amounts of the extract, which then acts at once as the active ingredient and the gelling agent. Infrared spectra of the respective mixtures proved that hydrogen bonds play a crucial role in the formation of the gel network. Dicarboxylic acids had almost no effect on gel strength. Monoalcohols increased the firmness of the oleogel with a decreasing effect from methanol > ethanol > butanol > octanol. All tested terminal diols increased the gel strength whereas vicinal diols affected the gel strength negatively. The effect was highly dependent on their concentration. The different effects of the diols are linked to their structure and polarity. The most pronounced enhancement of gelation was found for 1,6-hexanediol, which reduced the amount of triterpene extract (TE), which is necessary for the formation of an oleogel by a factor of 10. MDPI 2020-02-21 /pmc/articles/PMC7076353/ /pubmed/32098195 http://dx.doi.org/10.3390/pharmaceutics12020184 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ghaffar, Kashif Ahmad
Daniels, Rolf
Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives
title Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives
title_full Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives
title_fullStr Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives
title_full_unstemmed Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives
title_short Oleogels with Birch Bark Dry Extract: Extract Saving Formulations through Gelation Enhancing Additives
title_sort oleogels with birch bark dry extract: extract saving formulations through gelation enhancing additives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076353/
https://www.ncbi.nlm.nih.gov/pubmed/32098195
http://dx.doi.org/10.3390/pharmaceutics12020184
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