Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy

Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration. The polycation was synthesized by derivatization of α,β-poly(N-2-hydroxyethyl)d,l-aspartamide (PHEA) with 1,2-Bis(3-ami...

Descripción completa

Detalles Bibliográficos
Autores principales: Craparo, Emanuela Fabiola, Drago, Salvatore Emanuele, Mauro, Nicolò, Giammona, Gaetano, Cavallaro, Gennara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076449/
https://www.ncbi.nlm.nih.gov/pubmed/31979001
http://dx.doi.org/10.3390/pharmaceutics12020089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076449/
https://www.ncbi.nlm.nih.gov/pubmed/31979001
http://dx.doi.org/10.3390/pharmaceutics12020089

Ejemplares similares