Cargando…

Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy

Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration. The polycation was synthesized by derivatization of α,β-poly(N-2-hydroxyethyl)d,l-aspartamide (PHEA) with 1,2-Bis(3-ami...

Descripción completa

Detalles Bibliográficos
Autores principales:	Craparo, Emanuela Fabiola, Drago, Salvatore Emanuele, Mauro, Nicolò, Giammona, Gaetano, Cavallaro, Gennara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076449/ https://www.ncbi.nlm.nih.gov/pubmed/31979001 http://dx.doi.org/10.3390/pharmaceutics12020089

Ejemplares similares

Margination of Fluorescent Polylactic Acid–Polyaspartamide based Nanoparticles in Microcapillaries In Vitro: the Effect of Hematocrit and Pressure
por: Craparo, Emanuela Fabiola, et al.
Publicado: (2017)

Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy
por: Cavallaro, Gennara, et al.
Publicado: (2021)

Polyaspartamide-Based Nanoparticles Loaded with Fluticasone Propionate and the In Vitro Evaluation towards Cigarette Smoke Effects
por: Craparo, Emanuela Fabiola, et al.
Publicado: (2017)

Combining Inulin Multifunctional Polycation and Magnetic Nanoparticles: Redox-Responsive siRNA-Loaded Systems for Magnetofection
por: Sardo, Carla, et al.
Publicado: (2019)

Inhalable Formulation Based on Lipid–Polymer Hybrid Nanoparticles for the Macrophage Targeted Delivery of Roflumilast
por: Craparo, Emanuela F., et al.
Publicado: (2022)

Biomedical Applications of Polylactide (PLA) and Its Copolymers
por: Giammona, Gaetano, et al.
Publicado: (2018)

Carbon Nanodots as Functional Excipient to Develop Highly Stable and Smart PLGA Nanoparticles Useful in Cancer Theranostics
por: Mauro, Nicolò, et al.
Publicado: (2020)

Development of a novel rapamycin loaded nano- into micro-formulation for treatment of lung inflammation
por: Craparo, Emanuela Fabiola, et al.
Publicado: (2022)

Sustained-Release Powders Based on Polymer Particles for Pulmonary Delivery of Beclomethasone Dipropionate in the Treatment of Lung Inflammation
por: Craparo, Emanuela Fabiola, et al.
Publicado: (2023)

Rapamycin-Loaded Polymeric Nanoparticles as an Advanced Formulation for Macrophage Targeting in Atherosclerosis
por: Craparo, Emanuela Fabiola, et al.
Publicado: (2021)

Cholesterol-Inulin Conjugates for Efficient SN38 Nuclear Delivery: Nanomedicines for Precision Cancer Therapy
por: Mauro, Nicolò, et al.
Publicado: (2022)

Polymer-Based Systems for Controlled Release and Targeting of Drugs
por: Giammona, Gaetano, et al.
Publicado: (2019)

Carbon Nanodots for On Demand Chemophotothermal Therapy Combination to Elicit Necroptosis: Overcoming Apoptosis Resistance in Breast Cancer Cell Lines
por: Nicosia, Aldo, et al.
Publicado: (2020)

Pressure-Dependent Tuning of Photoluminescence and Size Distribution of Carbon Nanodots for Theranostic Anticancer Applications
por: Mauro, Nicolò, et al.
Publicado: (2020)

Temperature Responsive Nanoparticles Based on PEGylated Polyaspartamide Derivatives for Drug Delivery
por: Zhang, Guangyan, et al.
Publicado: (2019)

mPEG-PLGA Nanoparticles Labelled with Loaded or Conjugated Rhodamine-B for Potential Nose-to-Brain Delivery
por: Craparo, Emanuela Fabiola, et al.
Publicado: (2021)

Lipid nanoparticles as delivery vehicles for the Parietaria judaica major allergen Par j 2
por: Bondì, Maria Luisa, et al.
Publicado: (2011)

Addition of poly (propylene glycol) to multiblock copolymer to optimize siRNA delivery
por: Dai, Zhi, et al.
Publicado: (2014)

Drug Delivery of siRNA Therapeutics
por: Lamberti, Gaetano, et al.
Publicado: (2020)

The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells
por: Hartl, Natascha, et al.
Publicado: (2019)

A review on herbal antiasthmatics
por: Mali, Ravindra G., et al.
Publicado: (2011)

Targeted Delivery of siRNA
por: Oliveira, Sabrina, et al.
Publicado: (2006)

Dendrimers for siRNA Delivery
por: Biswas, Swati, et al.
Publicado: (2013)

Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells
por: Bondì, Maria Luisa, et al.
Publicado: (2014)

Polyaspartamide Functionalized Catechol-Based Hydrogels Embedded with Silver Nanoparticles for Antimicrobial Properties
por: Tan, Milène, et al.
Publicado: (2018)

Cariogenic Potential of Inhaled Antiasthmatic Drugs
por: Brigic, Amela, et al.
Publicado: (2015)

Branched polyethylenimine-grafted-carboxymethyl chitosan copolymer enhances the delivery of pDNA or siRNA in vitro and in vivo
por: Park, Seong-Cheol, et al.
Publicado: (2013)

Aptamer mediated siRNA delivery
por: Chu, Ted C., et al.
Publicado: (2006)

Pulmonary delivery of therapeutic siRNA
por: Lam, Jenny Ka-Wing, et al.
Publicado: (2012)

Intranasal Delivery of Antiviral siRNA
por: Barik, Sailen
Publicado: (2010)

Balanced Effects of Surface Reactivity and Self-Association of Bifunctional Polyaspartamide on Stem Cell Adhesion
por: Park, Jooyeon, et al.
Publicado: (2017)

Synthesis, antiasthmatic, and insecticidal/antifungal activities of allosamidins
por: Huang, Gangliang, et al.
Publicado: (2019)

Galactosylated Polymer/Gold Nanorods Nanocomposites for Sustained and Pulsed Chemo-Photothermal Treatments of Hepatocarcinoma
por: Giammona, Gaetano, et al.
Publicado: (2022)

Design of Cyclic Peptide-Based Nanospheres and the Delivery of siRNA
por: Ke, Junfeng, et al.
Publicado: (2022)

Correction to: Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells
por: Di Gesù, Roberto, et al.
Publicado: (2018)

Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics
por: Mauro, Nicolò, et al.
Publicado: (2021)

Advances in Lipid Nanoparticles for siRNA Delivery
por: Tam, Yuen Yi C., et al.
Publicado: (2013)

Bone site-specific delivery of siRNA
por: Liu, Xinli
Publicado: (2016)

Chaperonin–Dendrimer Conjugates for siRNA Delivery
por: Nussbaumer, Martin G., et al.
Publicado: (2016)

Amphiphilic Peptides for Efficient siRNA Delivery
por: Mozaffari, Saghar, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5s8vpc9qt3h3vsvcb7895qul0k