Cargando…
DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code
N(6)-methyladenine (6mA) is a DNA base modification at the 6th nitrogen position; recently, it has been resurfaced as a potential reversible epigenetic mark in eukaryotes. Despite its existence, 6mA was considered to be absent due to its undetectable level. However, with the new advancements in meth...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076483/ https://www.ncbi.nlm.nih.gov/pubmed/32075056 http://dx.doi.org/10.3390/plants9020247 |
_version_ | 1783507227353546752 |
---|---|
author | Karanthamalai, Jeyalakshmi Chodon, Aparna Chauhan, Shailja Pandi, Gopal |
author_facet | Karanthamalai, Jeyalakshmi Chodon, Aparna Chauhan, Shailja Pandi, Gopal |
author_sort | Karanthamalai, Jeyalakshmi |
collection | PubMed |
description | N(6)-methyladenine (6mA) is a DNA base modification at the 6th nitrogen position; recently, it has been resurfaced as a potential reversible epigenetic mark in eukaryotes. Despite its existence, 6mA was considered to be absent due to its undetectable level. However, with the new advancements in methods, considerable 6mA distribution is identified across the plant genome. Unlike 5-methylcytosine (5mC) in the gene promoter, 6mA does not have a definitive role in repression but is exposed to have divergent regulation in gene expression. Though 6mA information is less known, the available evidences suggest its function in plant development, tissue differentiation, and regulations in gene expression. The current review article emphasizes the research advances in DNA 6mA modifications, identification, available databases, analysis tools and its significance in plant development, cellular functions and future perspectives of research. |
format | Online Article Text |
id | pubmed-7076483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70764832020-03-20 DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code Karanthamalai, Jeyalakshmi Chodon, Aparna Chauhan, Shailja Pandi, Gopal Plants (Basel) Review N(6)-methyladenine (6mA) is a DNA base modification at the 6th nitrogen position; recently, it has been resurfaced as a potential reversible epigenetic mark in eukaryotes. Despite its existence, 6mA was considered to be absent due to its undetectable level. However, with the new advancements in methods, considerable 6mA distribution is identified across the plant genome. Unlike 5-methylcytosine (5mC) in the gene promoter, 6mA does not have a definitive role in repression but is exposed to have divergent regulation in gene expression. Though 6mA information is less known, the available evidences suggest its function in plant development, tissue differentiation, and regulations in gene expression. The current review article emphasizes the research advances in DNA 6mA modifications, identification, available databases, analysis tools and its significance in plant development, cellular functions and future perspectives of research. MDPI 2020-02-14 /pmc/articles/PMC7076483/ /pubmed/32075056 http://dx.doi.org/10.3390/plants9020247 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Karanthamalai, Jeyalakshmi Chodon, Aparna Chauhan, Shailja Pandi, Gopal DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code |
title | DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code |
title_full | DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code |
title_fullStr | DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code |
title_full_unstemmed | DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code |
title_short | DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code |
title_sort | dna n(6)-methyladenine modification in plant genomes—a glimpse into emerging epigenetic code |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076483/ https://www.ncbi.nlm.nih.gov/pubmed/32075056 http://dx.doi.org/10.3390/plants9020247 |
work_keys_str_mv | AT karanthamalaijeyalakshmi dnan6methyladeninemodificationinplantgenomesaglimpseintoemergingepigeneticcode AT chodonaparna dnan6methyladeninemodificationinplantgenomesaglimpseintoemergingepigeneticcode AT chauhanshailja dnan6methyladeninemodificationinplantgenomesaglimpseintoemergingepigeneticcode AT pandigopal dnan6methyladeninemodificationinplantgenomesaglimpseintoemergingepigeneticcode |