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DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code

N(6)-methyladenine (6mA) is a DNA base modification at the 6th nitrogen position; recently, it has been resurfaced as a potential reversible epigenetic mark in eukaryotes. Despite its existence, 6mA was considered to be absent due to its undetectable level. However, with the new advancements in meth...

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Autores principales: Karanthamalai, Jeyalakshmi, Chodon, Aparna, Chauhan, Shailja, Pandi, Gopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076483/
https://www.ncbi.nlm.nih.gov/pubmed/32075056
http://dx.doi.org/10.3390/plants9020247
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author Karanthamalai, Jeyalakshmi
Chodon, Aparna
Chauhan, Shailja
Pandi, Gopal
author_facet Karanthamalai, Jeyalakshmi
Chodon, Aparna
Chauhan, Shailja
Pandi, Gopal
author_sort Karanthamalai, Jeyalakshmi
collection PubMed
description N(6)-methyladenine (6mA) is a DNA base modification at the 6th nitrogen position; recently, it has been resurfaced as a potential reversible epigenetic mark in eukaryotes. Despite its existence, 6mA was considered to be absent due to its undetectable level. However, with the new advancements in methods, considerable 6mA distribution is identified across the plant genome. Unlike 5-methylcytosine (5mC) in the gene promoter, 6mA does not have a definitive role in repression but is exposed to have divergent regulation in gene expression. Though 6mA information is less known, the available evidences suggest its function in plant development, tissue differentiation, and regulations in gene expression. The current review article emphasizes the research advances in DNA 6mA modifications, identification, available databases, analysis tools and its significance in plant development, cellular functions and future perspectives of research.
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spelling pubmed-70764832020-03-20 DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code Karanthamalai, Jeyalakshmi Chodon, Aparna Chauhan, Shailja Pandi, Gopal Plants (Basel) Review N(6)-methyladenine (6mA) is a DNA base modification at the 6th nitrogen position; recently, it has been resurfaced as a potential reversible epigenetic mark in eukaryotes. Despite its existence, 6mA was considered to be absent due to its undetectable level. However, with the new advancements in methods, considerable 6mA distribution is identified across the plant genome. Unlike 5-methylcytosine (5mC) in the gene promoter, 6mA does not have a definitive role in repression but is exposed to have divergent regulation in gene expression. Though 6mA information is less known, the available evidences suggest its function in plant development, tissue differentiation, and regulations in gene expression. The current review article emphasizes the research advances in DNA 6mA modifications, identification, available databases, analysis tools and its significance in plant development, cellular functions and future perspectives of research. MDPI 2020-02-14 /pmc/articles/PMC7076483/ /pubmed/32075056 http://dx.doi.org/10.3390/plants9020247 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Karanthamalai, Jeyalakshmi
Chodon, Aparna
Chauhan, Shailja
Pandi, Gopal
DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code
title DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code
title_full DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code
title_fullStr DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code
title_full_unstemmed DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code
title_short DNA N(6)-Methyladenine Modification in Plant Genomes—A Glimpse into Emerging Epigenetic Code
title_sort dna n(6)-methyladenine modification in plant genomes—a glimpse into emerging epigenetic code
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076483/
https://www.ncbi.nlm.nih.gov/pubmed/32075056
http://dx.doi.org/10.3390/plants9020247
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