Cargando…

Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells

Multidrug resistance (MDR) is a critical hindrance to the success of cancer chemotherapy. The main thing responsible for MDR phenotypes are plasma-membranes associated with adenosine triphosphate (ATP) Binding Cassette (ABC) drug efflux transporters, such as the P-glycoprotein (Pgp) transporter that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fathy Abd-Ellatef, Gamal-Eldein, Gazzano, Elena, Chirio, Daniela, Ragab Hamed, Ahmed, Belisario, Dimas Carolina, Zuddas, Carlo, Peira, Elena, Rolando, Barbara, Kopecka, Joanna, Assem Said Marie, Mohamed, Sapino, Simona, Ramadan Fahmy, Sohair, Gallarate, Marina, Zaki Abdel-Hamid, Abdel-Hamid, Riganti, Chiara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076516/ https://www.ncbi.nlm.nih.gov/pubmed/31991669 http://dx.doi.org/10.3390/pharmaceutics12020096

Ejemplares similares

Calcium Phosphate-Coated Lipid Nanoparticles as a Potential Tool in Bone Diseases Therapy
por: Sapino, Simona, et al.
Publicado: (2021)

Naked and Decorated Nanoparticles Containing H(2)S-Releasing Doxorubicin: Preparation, Characterization and Assessment of Their Antitumoral Efficiency on Various Resistant Tumor Cells
por: Peira, Elena, et al.
Publicado: (2022)

Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer
por: Salaroglio, Iris C., et al.
Publicado: (2018)

Recent Advances in Nanosystems and Strategies for Vaginal Delivery of Antimicrobials
por: Chindamo, Giulia, et al.
Publicado: (2021)

Doxorubicin-Loaded Lipid Nanoparticles Coated with Calcium Phosphate as a Potential Tool in Human and Canine Osteosarcoma Therapy
por: Chirio, Daniela, et al.
Publicado: (2022)

Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
por: Chindamo, Giulia, et al.
Publicado: (2020)

Nanocarriers in Veterinary Medicine: A Challenge for Improving Osteosarcoma Conventional Treatments
por: Sapino, Simona, et al.
Publicado: (2022)

Ulva lactuca polysaccharides prevent Wistar rat breast carcinogenesis through the augmentation of apoptosis, enhancement of antioxidant defense system, and suppression of inflammation
por: Abd-Ellatef, Gamal-Eldein F, et al.
Publicado: (2017)

Stearoyl-Chitosan Coated Nanoparticles Obtained by Microemulsion Cold Dilution Technique
por: Chirio, Daniela, et al.
Publicado: (2018)

Development of ARPE-19-Equipped Ocular Cell Model for In Vitro Investigation on Ophthalmic Formulations
por: Sapino, Simona, et al.
Publicado: (2023)

Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach
por: Sapino, Simona, et al.
Publicado: (2019)

Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab
por: Peira, Elena, et al.
Publicado: (2021)

Development of Solid Lipid Nanoparticles by Cold Dilution of Microemulsions: Curcumin Loading, Preliminary In Vitro Studies, and Biodistribution
por: Chirio, Daniela, et al.
Publicado: (2019)

A New Bevacizumab Carrier for Intravitreal Administration: Focus on Stability
por: Chirio, Daniela, et al.
Publicado: (2021)

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast
por: Doublier, Sophie, et al.
Publicado: (2012)

An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells
por: Campia, Ivana, et al.
Publicado: (2015)

Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells
por: Gazzano, Elena, et al.
Publicado: (2018)

Developing Actively Targeted Nanoparticles to Fight Cancer: Focus on Italian Research
por: Argenziano, Monica, et al.
Publicado: (2021)

Thermosensitive Nanocomposite Hydrogels for Intravitreal Delivery of Cefuroxime
por: Sapino, Simona, et al.
Publicado: (2019)

ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer
por: Salaroglio, Iris C., et al.
Publicado: (2019)

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells
por: De Boo, Sara, et al.
Publicado: (2009)

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance
por: Belisario, Dimas Carolina, et al.
Publicado: (2020)

Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
por: Akman, Muhlis, et al.
Publicado: (2021)

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma
por: Salaroglio, Iris Chiara, et al.
Publicado: (2014)

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death
por: Kopecka, Joanna, et al.
Publicado: (2020)

Cannabis-Based Oral Emulsion for Medical Purposes to Meet the Needs of Patients: Formulation, Quality and Stability
por: Baratta, Francesca, et al.
Publicado: (2022)

Development and Characterization of Solid Lipid Nanoparticles Loaded with a Highly Active Doxorubicin Derivative
por: Stella, Barbara, et al.
Publicado: (2018)

New Tetrahydroisoquinoline Derivatives Overcome Pgp Activity in Brain-Blood Barrier and Glioblastoma Multiforme in Vitro
por: Salaroglio, Iris Chiara, et al.
Publicado: (2018)

Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors
por: Kopecka, Joanna, et al.
Publicado: (2016)

Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition
por: Gelsomino, Giada, et al.
Publicado: (2013)

Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells
por: Kopecka, Joanna, et al.
Publicado: (2015)

ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma
por: Belisario, Dimas Carolina, et al.
Publicado: (2020)

SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma
por: Salaroglio, Iris Chiara, et al.
Publicado: (2022)

Overcoming drug resistance in glioblastoma: new options in sight?
por: Kopecka, Joanna, et al.
Publicado: (2021)

Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer
por: Salaroglio, Iris C., et al.
Publicado: (2022)

Editorial: Novel therapeutic approaches to target drug resistant tumors
por: Riganti, Chiara, et al.
Publicado: (2023)

Potential immunotherapeutic role of interleukin-2 and interleukin-12 combination in patients with hepatocellular carcinoma
por: Gabeen, Abdulwahab Ali, et al.
Publicado: (2014)

Anti-fibrotic effect of Holothuria arenicola extract against bile duct ligation in rats
por: Fahmy, Sohair R
Publicado: (2015)

Virologic response and breakthrough in chronic hepatitis B Egyptian patients receiving lamivudine therapy
por: Ismail, Sohair, et al.
Publicado: (2014)

Identification of Redox-Sensitive Transcription Factors as Markers of Malignant Pleural Mesothelioma
por: Schiavello, Martina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ofa21m0sripk29jj21ep14dioe