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Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes
Cullin-RING E3 ligase (CRL) is the largest family of E3 ubiquitin ligase, responsible for ubiquitylation of ∼20% of cellular proteins. CRL plays an important role in many biological processes, particularly in cancers due to abnormal activation. CRL activation requires neddylation, an enzymatic casca...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Neoplasia Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076571/ https://www.ncbi.nlm.nih.gov/pubmed/32145688 http://dx.doi.org/10.1016/j.neo.2020.02.003 |