Improving the Oral Bioavailability of an Anti-Glioma Prodrug CAT3 Using Novel Solid Lipid Nanoparticles Containing Oleic Acid-CAT3 Conjugates

13a-(S)-3-pivaloyloxyl-6,7-dimethoxyphenanthro(9,10-b)-indolizidine (CAT3) is a novel oral anti-glioma pro-drug with a potent anti-tumor effect against temozolomide-resistant glioma in vivo. However, poor lipid solubility has limited the encapsulation efficacy during formulation development. Moreove...

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Detalles Bibliográficos
Autores principales: Wang, Hongliang, Li, Lin, Ye, Jun, Wang, Rubing, Wang, Renyun, Hu, Jinping, Wang, Yanan, Dong, Wujun, Xia, Xuejun, Yang, Yanfang, Gao, Yue, Gao, Lili, Liu, Yuling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076672/
https://www.ncbi.nlm.nih.gov/pubmed/32028734
http://dx.doi.org/10.3390/pharmaceutics12020126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076672/
https://www.ncbi.nlm.nih.gov/pubmed/32028734
http://dx.doi.org/10.3390/pharmaceutics12020126

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