LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

The Hippo and mTORC1 pathways are the two predominant growth-control pathways that dictate proper organ development. We therefore explored a possible crosstalk between these two functional relevant pathways to coordinate their growth-control functions. We found that the LATS1/2 kinases, the core com...

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Detalles Bibliográficos
Autores principales: Gan, Wenjian, Dai, Xiaoming, Dai, Xiangpeng, Xie, Jun, Yin, Shasha, Zhu, Junjie, Wang, Chen, Liu, Yuchen, Guo, Jianping, Wang, Min, Liu, Jing, Hu, Jia, Quinton, Ryan J., Ganem, Neil J., Liu, Pengda, Asara, John M., Pandolfi, Pier Paolo, Yang, Yingzi, He, Zhigang, Gao, Guangping, Wei, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076906/
https://www.ncbi.nlm.nih.gov/pubmed/32015438
http://dx.doi.org/10.1038/s41556-020-0463-6

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