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Risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression

BACKGROUND: A limited number of publications have assessed the prevalence of hypertension (HTN) in polycystic ovary syndrome (PCOS) patients with inconclusive results. Since in general populations the occurrence of hypertension is related to age per se, we investigated the prevalence (P) / relative...

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Autores principales: Amiri, Mina, Ramezani Tehrani, Fahimeh, Behboudi-Gandevani, Samira, Bidhendi-Yarandi, Razieh, Carmina, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076940/
https://www.ncbi.nlm.nih.gov/pubmed/32183820
http://dx.doi.org/10.1186/s12958-020-00576-1
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author Amiri, Mina
Ramezani Tehrani, Fahimeh
Behboudi-Gandevani, Samira
Bidhendi-Yarandi, Razieh
Carmina, Enrico
author_facet Amiri, Mina
Ramezani Tehrani, Fahimeh
Behboudi-Gandevani, Samira
Bidhendi-Yarandi, Razieh
Carmina, Enrico
author_sort Amiri, Mina
collection PubMed
description BACKGROUND: A limited number of publications have assessed the prevalence of hypertension (HTN) in polycystic ovary syndrome (PCOS) patients with inconclusive results. Since in general populations the occurrence of hypertension is related to age per se, we investigated the prevalence (P) / relative risk (RR) of HTN in pooled patients with PCOS, vs control population among reproductive age women with PCOS, compared to menopause/aging patients. METHODS: PubMed, Scopus, ScienceDirect, web of science, and Google scholar were systematically searched for retrieving observational studies published from inception to April 2019 investigating the HTN in patients with PCOS. The primary outcome of interest was pooled P and RR of HTN in reproductive and menopausal/aging women with PCOS compared to control population. RESULTS: The pooled prevalence of HTN in reproductive and menopausal/aging women with PCOS was higher than in the control population [(Pooled P: 0.15, 95% CI: 0.12–0.18 vs. Pooled P: 0.09, 95% CI: 0.08–0.10) and (Pooled P: 0.49, 95% CI: 0.28–0.70 vs. Pooled P: 0.40, 95% CI: 0.22–0.57), respectively]. Compared to the control population, pooled relative risk (RR) of HTN patients was increased only in reproductive age PCOS (1.70-fold, 95% CI: 1.43–2.07) but not in menopausal/aging patients who had PCOS during their reproductive years. The same results were obtained for subgroups of population-based studies. Meta-regression analysis of population-based studies showed that the RR of HTN in reproductive age PCOS patients was 1.76-fold than menopausal/aging PCOS patients (P = 0.262). CONCLUSION: This meta-analysis confirms a greater risk of HTN in PCOS patients but demonstrates that this risk is increased only in reproductive age women with PCOS, indicating that after menopause, having a history of PCOS may not be as an important predisposing factor for developing HTN.
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spelling pubmed-70769402020-03-18 Risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression Amiri, Mina Ramezani Tehrani, Fahimeh Behboudi-Gandevani, Samira Bidhendi-Yarandi, Razieh Carmina, Enrico Reprod Biol Endocrinol Review BACKGROUND: A limited number of publications have assessed the prevalence of hypertension (HTN) in polycystic ovary syndrome (PCOS) patients with inconclusive results. Since in general populations the occurrence of hypertension is related to age per se, we investigated the prevalence (P) / relative risk (RR) of HTN in pooled patients with PCOS, vs control population among reproductive age women with PCOS, compared to menopause/aging patients. METHODS: PubMed, Scopus, ScienceDirect, web of science, and Google scholar were systematically searched for retrieving observational studies published from inception to April 2019 investigating the HTN in patients with PCOS. The primary outcome of interest was pooled P and RR of HTN in reproductive and menopausal/aging women with PCOS compared to control population. RESULTS: The pooled prevalence of HTN in reproductive and menopausal/aging women with PCOS was higher than in the control population [(Pooled P: 0.15, 95% CI: 0.12–0.18 vs. Pooled P: 0.09, 95% CI: 0.08–0.10) and (Pooled P: 0.49, 95% CI: 0.28–0.70 vs. Pooled P: 0.40, 95% CI: 0.22–0.57), respectively]. Compared to the control population, pooled relative risk (RR) of HTN patients was increased only in reproductive age PCOS (1.70-fold, 95% CI: 1.43–2.07) but not in menopausal/aging patients who had PCOS during their reproductive years. The same results were obtained for subgroups of population-based studies. Meta-regression analysis of population-based studies showed that the RR of HTN in reproductive age PCOS patients was 1.76-fold than menopausal/aging PCOS patients (P = 0.262). CONCLUSION: This meta-analysis confirms a greater risk of HTN in PCOS patients but demonstrates that this risk is increased only in reproductive age women with PCOS, indicating that after menopause, having a history of PCOS may not be as an important predisposing factor for developing HTN. BioMed Central 2020-03-17 /pmc/articles/PMC7076940/ /pubmed/32183820 http://dx.doi.org/10.1186/s12958-020-00576-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Amiri, Mina
Ramezani Tehrani, Fahimeh
Behboudi-Gandevani, Samira
Bidhendi-Yarandi, Razieh
Carmina, Enrico
Risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression
title Risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression
title_full Risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression
title_fullStr Risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression
title_full_unstemmed Risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression
title_short Risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression
title_sort risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076940/
https://www.ncbi.nlm.nih.gov/pubmed/32183820
http://dx.doi.org/10.1186/s12958-020-00576-1
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