ITR-Seq, a next-generation sequencing assay, identifies genome-wide DNA editing sites in vivo following adeno-associated viral vector-mediated genome editing

BACKGROUND: Identifying nuclease-induced double-stranded breaks in DNA on a genome-wide scale is critical for assessing the safety and efficacy of genome editing therapies. We previously demonstrated that after administering adeno-associated viral (AAV) vector-mediated genome-editing strategies in v...

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Detalles Bibliográficos
Autores principales: Breton, Camilo, Clark, Peter M., Wang, Lili, Greig, Jenny A., Wilson, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076944/
https://www.ncbi.nlm.nih.gov/pubmed/32183699
http://dx.doi.org/10.1186/s12864-020-6655-4

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