Cargando…

Exosomal miRNA-128-3p from mesenchymal stem cells of aged rats regulates osteogenesis and bone fracture healing by targeting Smad5

Transplantation of mesenchymal stem cells (MSCs) has been considered an effective therapeutic treatment for a variety of diseases including bone fracture. However, there are associated complications along with MSCs transplantation. There is evidence to show that exosomes (Exos) derived from MSCs exe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Tao, Luo, Yongjun, Wang, Jiaxing, Zhang, Ning, Gu, Changjiang, Li, Linwei, Qian, Dingfei, Cai, Weihua, Fan, Jin, Yin, Guoyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077029/ https://www.ncbi.nlm.nih.gov/pubmed/32178675 http://dx.doi.org/10.1186/s12951-020-00601-w

Ejemplares similares

miR-1323 suppresses bone mesenchymal stromal cell osteogenesis and fracture healing via inhibiting BMP4/SMAD4 signaling
por: Xie, Hui, et al.
Publicado: (2020)

Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion
por: Zhang, Lu, et al.
Publicado: (2020)

Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy
por: Gu, Changjiang, et al.
Publicado: (2020)

GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF‐κB/Notch signalling to promote angiogenesis
por: Li, Linwei, et al.
Publicado: (2019)

Staphylococcal enterotoxin C2 promotes osteogenesis of mesenchymal stem cells and accelerates fracture healing
por: Wu, T., et al.
Publicado: (2018)

Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta()()
por: Sun, Bin, et al.
Publicado: (2022)

Ginsenoside Rg1 promotes osteogenic differentiation of rBMSCs and healing of rat tibial fractures through regulation of GR-dependent BMP-2/SMAD signaling
por: Gu, Yanqing, et al.
Publicado: (2016)

Mechanical force induces macrophage-derived exosomal UCHL3 promoting bone marrow mesenchymal stem cell osteogenesis by targeting SMAD1
por: Pu, Panjun, et al.
Publicado: (2023)

Irisin promotes fracture healing by improving osteogenesis and angiogenesis
por: Kan, Tianyou, et al.
Publicado: (2022)

miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells
por: Luo, Yongjun, et al.
Publicado: (2019)

Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3
por: Liu, Hengchen, et al.
Publicado: (2021)

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization
por: Liu, Wei, et al.
Publicado: (2020)

Amygdalin Promotes Fracture Healing through TGF-β/Smad Signaling in Mesenchymal Stem Cells
por: Ying, Jun, et al.
Publicado: (2020)

Ginsenoside Compound K Enhances Fracture Healing via Promoting Osteogenesis and Angiogenesis
por: Ding, Lingli, et al.
Publicado: (2022)

Cyasterone accelerates fracture healing by promoting MSCs migration and osteogenesis
por: Zhu, Junlang, et al.
Publicado: (2021)

Radiation Can Regulate the Expression of miRNAs Associated with Osteogenesis and Oxidation in Exosomes from Peripheral Blood Plasma
por: Du, Yu, et al.
Publicado: (2021)

A Reciprocal Role of the Smad4‐Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells
por: Park, Jin Seok, et al.
Publicado: (2018)

Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling
por: Bai, Jian, et al.
Publicado: (2021)

MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1
por: Zhang, Dong, et al.
Publicado: (2021)

Corrigendum: Ginsenoside Compound K Enhances Fracture Healing via Promoting Osteogenesis and Angiogenesis
por: Ding, Lingli, et al.
Publicado: (2022)

Gukang Capsule Promotes Fracture Healing by Activating BMP/SMAD and Wnt/β-Catenin Signaling Pathways
por: Ma, Xue, et al.
Publicado: (2020)

Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway
por: Liu, Tao, et al.
Publicado: (2019)

A Dual Peptide Sustained-Release System Based on Nanohydroxyapatite/Polyamide 66 Scaffold for Synergistic-Enhancing Diabetic Rats’ Fracture Healing in Osteogenesis and Angiogenesis
por: Li, Jian, et al.
Publicado: (2021)

Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway
por: Jiang, Tiechao, et al.
Publicado: (2020)

The role of Exosomal miRNAs in cancer
por: Li, Chuanyun, et al.
Publicado: (2022)

M2 macrophage-derived exosome-encapsulated microneedles with mild photothermal therapy for accelerated diabetic wound healing
por: Zeng, Junkai, et al.
Publicado: (2023)

Lnk-dependent axis of SCF–cKit signal for osteogenesis in bone fracture healing
por: Matsumoto, Tomoyuki, et al.
Publicado: (2010)

MiRNA-10b Reciprocally Stimulates Osteogenesis and Inhibits Adipogenesis Partly through the TGF-β/SMAD2 Signaling Pathway
por: Li, Hongling, et al.
Publicado: (2018)

Analysis of the miRNA and mRNA involved in osteogenesis of adipose-derived mesenchymal stem cells
por: Jia, Bo, et al.
Publicado: (2018)

Functions of MiRNA-128 on the Regulation of Head and Neck Squamous Cell Carcinoma Growth and Apoptosis
por: Hauser, Belinda, et al.
Publicado: (2015)

Exosomal miR‐128‐3p reversed fibrinogen‐mediated inhibition of oligodendrocyte progenitor cell differentiation and remyelination after cerebral ischemia
por: Hou, Huiqing, et al.
Publicado: (2023)

Mechanisms of miR-128-3p in inhibiting osteoblast differentiation from bone marrow-derived mesenchymal stromal cells
por: Zhang, Wen, et al.
Publicado: (2020)

MiRNA-320a-5p contributes to the homeostasis of osteogenesis and adipogenesis in bone marrow mesenchymal stem cell
por: Zhang, Ying, et al.
Publicado: (2022)

The Role and Mechanism of Exosomes from Umbilical Cord Mesenchymal Stem Cells in Inducing Osteogenesis and Preventing Osteoporosis
por: Yahao, Ge, et al.
Publicado: (2021)

Erratum to “MiRNA-10b Reciprocally Stimulates Osteogenesis and Inhibits Adipogenesis Partly through the TGF-β/SMAD2 Signaling Pathway”
por: Li, Hongling, et al.
Publicado: (2021)

Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway
por: Li, Na, et al.
Publicado: (2016)

Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation
por: Kuang, Wei, et al.
Publicado: (2017)

Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling
por: Wang, Xiao, et al.
Publicado: (2019)

mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
por: Li, Yi, et al.
Publicado: (2021)

Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury
por: Feng, Jia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m8kj5a4volnkshegn46rjg9ltf