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Adverse pregnancy outcomes among women presenting at antenatal clinics in Ouélessébougou, Mali
BACKGROUND: In sub-Saharan Africa, malaria continues to scourge the population and is the primary cause of morbidity and mortality in young children and pregnant women. As current preventative measures such as intermittent preventive treatment and use of insecticide-treated nets provide incomplete p...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077143/ https://www.ncbi.nlm.nih.gov/pubmed/32183832 http://dx.doi.org/10.1186/s12978-020-0890-7 |
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author | Andemel, Naissem Gaoussou, Santara Barry, Amadou Issiaka, Djibrilla Mahamar, Almahamoudou Traore, Moussa Duffy, Patrick E. Dicko, Alassane Fried, Michal |
author_facet | Andemel, Naissem Gaoussou, Santara Barry, Amadou Issiaka, Djibrilla Mahamar, Almahamoudou Traore, Moussa Duffy, Patrick E. Dicko, Alassane Fried, Michal |
author_sort | Andemel, Naissem |
collection | PubMed |
description | BACKGROUND: In sub-Saharan Africa, malaria continues to scourge the population and is the primary cause of morbidity and mortality in young children and pregnant women. As current preventative measures such as intermittent preventive treatment and use of insecticide-treated nets provide incomplete protection, several malaria vaccines are currently under development, including one to specifically prevent pregnancy malaria. Prior to conducting vaccine trials, it is important to obtain background information on poor pregnancy outcomes in the target population to establish a baseline. METHODS: Pregnant women presenting at community health care centers for antenatal care were recruited to the study. Gestational age was determined by ultrasound examination following recruitment. Antenatal care and pregnancy outcome information were collected during a visit 4–8 weeks post-delivery. RESULTS: One thousand eight hundred fifty women completed the study, and analysis included 1814 women after excluding multiple gestations (n = 26) and missing/incomplete data (n = 10). The percentage (95% CI) of adverse pregnancy outcomes is as follows: miscarriage, 0.28% (0.04–0.52); stillbirth, 1.93% (1.30–2.56); early neonatal death, 1.65% (1.03–2.24); late neonatal death, 0.39%, (0.10–0.68); and preterm delivery (PTD), 4.74% (3.76–5.73). The percentages of early and late neonatal deaths and PTD were significantly higher (p < 0.01) in primigravid compared to multigravid women. In primigravidae, 3.1, 1.1 and 7.1% of pregnancies resulted in early neonatal death, late neonatal death and PTD, respectively, while these outcomes in multigravidae were 1.0, 0.1 and 2.7%, respectively. Major malformations were identified in 4 newborns. CONCLUSIONS: Low gravidity and young age predict perinatal death and PTD. The information collected here can be used as a baseline for adverse pregnancy outcomes in future vaccine trials in pregnant women. |
format | Online Article Text |
id | pubmed-7077143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70771432020-03-19 Adverse pregnancy outcomes among women presenting at antenatal clinics in Ouélessébougou, Mali Andemel, Naissem Gaoussou, Santara Barry, Amadou Issiaka, Djibrilla Mahamar, Almahamoudou Traore, Moussa Duffy, Patrick E. Dicko, Alassane Fried, Michal Reprod Health Research BACKGROUND: In sub-Saharan Africa, malaria continues to scourge the population and is the primary cause of morbidity and mortality in young children and pregnant women. As current preventative measures such as intermittent preventive treatment and use of insecticide-treated nets provide incomplete protection, several malaria vaccines are currently under development, including one to specifically prevent pregnancy malaria. Prior to conducting vaccine trials, it is important to obtain background information on poor pregnancy outcomes in the target population to establish a baseline. METHODS: Pregnant women presenting at community health care centers for antenatal care were recruited to the study. Gestational age was determined by ultrasound examination following recruitment. Antenatal care and pregnancy outcome information were collected during a visit 4–8 weeks post-delivery. RESULTS: One thousand eight hundred fifty women completed the study, and analysis included 1814 women after excluding multiple gestations (n = 26) and missing/incomplete data (n = 10). The percentage (95% CI) of adverse pregnancy outcomes is as follows: miscarriage, 0.28% (0.04–0.52); stillbirth, 1.93% (1.30–2.56); early neonatal death, 1.65% (1.03–2.24); late neonatal death, 0.39%, (0.10–0.68); and preterm delivery (PTD), 4.74% (3.76–5.73). The percentages of early and late neonatal deaths and PTD were significantly higher (p < 0.01) in primigravid compared to multigravid women. In primigravidae, 3.1, 1.1 and 7.1% of pregnancies resulted in early neonatal death, late neonatal death and PTD, respectively, while these outcomes in multigravidae were 1.0, 0.1 and 2.7%, respectively. Major malformations were identified in 4 newborns. CONCLUSIONS: Low gravidity and young age predict perinatal death and PTD. The information collected here can be used as a baseline for adverse pregnancy outcomes in future vaccine trials in pregnant women. BioMed Central 2020-03-17 /pmc/articles/PMC7077143/ /pubmed/32183832 http://dx.doi.org/10.1186/s12978-020-0890-7 Text en © The Author(s). 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Andemel, Naissem Gaoussou, Santara Barry, Amadou Issiaka, Djibrilla Mahamar, Almahamoudou Traore, Moussa Duffy, Patrick E. Dicko, Alassane Fried, Michal Adverse pregnancy outcomes among women presenting at antenatal clinics in Ouélessébougou, Mali |
title | Adverse pregnancy outcomes among women presenting at antenatal clinics in Ouélessébougou, Mali |
title_full | Adverse pregnancy outcomes among women presenting at antenatal clinics in Ouélessébougou, Mali |
title_fullStr | Adverse pregnancy outcomes among women presenting at antenatal clinics in Ouélessébougou, Mali |
title_full_unstemmed | Adverse pregnancy outcomes among women presenting at antenatal clinics in Ouélessébougou, Mali |
title_short | Adverse pregnancy outcomes among women presenting at antenatal clinics in Ouélessébougou, Mali |
title_sort | adverse pregnancy outcomes among women presenting at antenatal clinics in ouélessébougou, mali |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077143/ https://www.ncbi.nlm.nih.gov/pubmed/32183832 http://dx.doi.org/10.1186/s12978-020-0890-7 |
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