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Replication Compartments of DNA Viruses in the Nucleus: Location, Location, Location
DNA viruses that replicate in the nucleus encompass a range of ubiquitous and clinically important viruses, from acute pathogens to persistent tumor viruses. These viruses must co-opt nuclear processes for the benefit of the virus, whilst evading host processes that would otherwise attenuate viral r...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077188/ https://www.ncbi.nlm.nih.gov/pubmed/32013091 http://dx.doi.org/10.3390/v12020151 |
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author | Charman, Matthew Weitzman, Matthew D. |
author_facet | Charman, Matthew Weitzman, Matthew D. |
author_sort | Charman, Matthew |
collection | PubMed |
description | DNA viruses that replicate in the nucleus encompass a range of ubiquitous and clinically important viruses, from acute pathogens to persistent tumor viruses. These viruses must co-opt nuclear processes for the benefit of the virus, whilst evading host processes that would otherwise attenuate viral replication. Accordingly, DNA viruses induce the formation of membraneless assemblies termed viral replication compartments (VRCs). These compartments facilitate the spatial organization of viral processes and regulate virus–host interactions. Here, we review advances in our understanding of VRCs. We cover their initiation and formation, their function as the sites of viral processes, and aspects of their composition and organization. In doing so, we highlight ongoing and emerging areas of research highly pertinent to our understanding of nuclear-replicating DNA viruses. |
format | Online Article Text |
id | pubmed-7077188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70771882020-03-20 Replication Compartments of DNA Viruses in the Nucleus: Location, Location, Location Charman, Matthew Weitzman, Matthew D. Viruses Review DNA viruses that replicate in the nucleus encompass a range of ubiquitous and clinically important viruses, from acute pathogens to persistent tumor viruses. These viruses must co-opt nuclear processes for the benefit of the virus, whilst evading host processes that would otherwise attenuate viral replication. Accordingly, DNA viruses induce the formation of membraneless assemblies termed viral replication compartments (VRCs). These compartments facilitate the spatial organization of viral processes and regulate virus–host interactions. Here, we review advances in our understanding of VRCs. We cover their initiation and formation, their function as the sites of viral processes, and aspects of their composition and organization. In doing so, we highlight ongoing and emerging areas of research highly pertinent to our understanding of nuclear-replicating DNA viruses. MDPI 2020-01-29 /pmc/articles/PMC7077188/ /pubmed/32013091 http://dx.doi.org/10.3390/v12020151 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Charman, Matthew Weitzman, Matthew D. Replication Compartments of DNA Viruses in the Nucleus: Location, Location, Location |
title | Replication Compartments of DNA Viruses in the Nucleus: Location, Location, Location |
title_full | Replication Compartments of DNA Viruses in the Nucleus: Location, Location, Location |
title_fullStr | Replication Compartments of DNA Viruses in the Nucleus: Location, Location, Location |
title_full_unstemmed | Replication Compartments of DNA Viruses in the Nucleus: Location, Location, Location |
title_short | Replication Compartments of DNA Viruses in the Nucleus: Location, Location, Location |
title_sort | replication compartments of dna viruses in the nucleus: location, location, location |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077188/ https://www.ncbi.nlm.nih.gov/pubmed/32013091 http://dx.doi.org/10.3390/v12020151 |
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