How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate...

Descripción completa

Detalles Bibliográficos
Autores principales: Marques, Cíntia, Som, Claudia, Schmutz, Mélanie, Borges, Olga, Borchard, Gerrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077258/
https://www.ncbi.nlm.nih.gov/pubmed/32211394
http://dx.doi.org/10.3389/fbioe.2020.00165
_version_ 1783507391766069248
author Marques, Cíntia
Som, Claudia
Schmutz, Mélanie
Borges, Olga
Borchard, Gerrit
author_facet Marques, Cíntia
Som, Claudia
Schmutz, Mélanie
Borges, Olga
Borchard, Gerrit
author_sort Marques, Cíntia
collection PubMed
description Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.
format Online
Article
Text
id pubmed-7077258
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-70772582020-03-24 How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept Marques, Cíntia Som, Claudia Schmutz, Mélanie Borges, Olga Borchard, Gerrit Front Bioeng Biotechnol Bioengineering and Biotechnology Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems. Frontiers Media S.A. 2020-03-10 /pmc/articles/PMC7077258/ /pubmed/32211394 http://dx.doi.org/10.3389/fbioe.2020.00165 Text en Copyright © 2020 Marques, Som, Schmutz, Borges and Borchard. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Marques, Cíntia
Som, Claudia
Schmutz, Mélanie
Borges, Olga
Borchard, Gerrit
How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title_full How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title_fullStr How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title_full_unstemmed How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title_short How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title_sort how the lack of chitosan characterization precludes implementation of the safe-by-design concept
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077258/
https://www.ncbi.nlm.nih.gov/pubmed/32211394
http://dx.doi.org/10.3389/fbioe.2020.00165
work_keys_str_mv AT marquescintia howthelackofchitosancharacterizationprecludesimplementationofthesafebydesignconcept
AT somclaudia howthelackofchitosancharacterizationprecludesimplementationofthesafebydesignconcept
AT schmutzmelanie howthelackofchitosancharacterizationprecludesimplementationofthesafebydesignconcept
AT borgesolga howthelackofchitosancharacterizationprecludesimplementationofthesafebydesignconcept
AT borchardgerrit howthelackofchitosancharacterizationprecludesimplementationofthesafebydesignconcept

Ejemplares similares