Cargando…

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence

While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound. The persistence of this stable HIV-1 latent reservoir forms the major barrier in HIV-1 cure research. The need for a better understanding...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lambrechts, Laurens, Cole, Basiel, Rutsaert, Sofie, Trypsteen, Wim, Vandekerckhove, Linos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077278/ https://www.ncbi.nlm.nih.gov/pubmed/32012811 http://dx.doi.org/10.3390/v12020149

Ejemplares similares

Digital PCR as a tool to measure HIV persistence
por: Rutsaert, Sofie, et al.
Publicado: (2018)

Diagnostic utility of droplet digital PCR for HIV reservoir quantification
por: Trypsteen, Wim, et al.
Publicado: (2016)

HIV-PULSE: a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization
por: Lambrechts, Laurens, et al.
Publicado: (2023)

Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1: a Phase IIa randomised controlled study
por: Rutsaert, Sofie, et al.
Publicado: (2019)

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia
por: Cole, Basiel, et al.
Publicado: (2021)

Highlights from the HIV Cure and Reservoir Symposium, 11–12 September 2017, Ghent, Belgium
por: Kint, Sam, et al.
Publicado: (2018)

In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes
por: Rutsaert, Sofie, et al.
Publicado: (2018)

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
por: Zhang, Zhenhua, et al.
Publicado: (2021)

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption
por: Cole, Basiel, et al.
Publicado: (2022)

Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors
por: Van Hecke, Clarissa, et al.
Publicado: (2019)

Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on‐going viral transcription
por: Pannus, Pieter, et al.
Publicado: (2020)

Evaluating lncRNA Expression Patterns during HIV-1 Treatment Interruption
por: Schynkel, Tinus, et al.
Publicado: (2023)

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs
por: Malatinkova, Eva, et al.
Publicado: (2015)

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation
por: Van de Wijer, Lisa, et al.
Publicado: (2021)

Accurate episomal HIV 2-LTR circles quantification using optimized DNA isolation and droplet digital PCR
por: Malatinkova, Eva, et al.
Publicado: (2014)

The impact of nevirapine- versus protease inhibitor-based regimens on virological markers of HIV-1 persistence during seemingly suppressive ART
por: Kiselinova, Maja, et al.
Publicado: (2014)

Interferon-Mediated Long Non-Coding RNA Response in Macrophages in the Context of HIV
por: Schynkel, Tinus, et al.
Publicado: (2020)

HIV Reservoir Characterization Symposium: 19 September 2016, Ghent, Belgium
por: Malatinkova, Eva, et al.
Publicado: (2017)

Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals
por: Kint, Sam, et al.
Publicado: (2020)

On the whereabouts of SARS-CoV-2 in the human body: A systematic review
por: Trypsteen, Wim, et al.
Publicado: (2020)

Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human Alu Repeat Sequences
por: Malatinkova, Eva, et al.
Publicado: (2021)

Motivations, barriers and experiences of participants in an HIV reservoir trial
por: De Scheerder, Marie-Angélique, et al.
Publicado: (2021)

Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay
por: Trypsteen, Wim, et al.
Publicado: (2016)

Comparison of Droplet Digital PCR and Seminested Real-Time PCR for Quantification of Cell-Associated HIV-1 RNA
por: Kiselinova, Maja, et al.
Publicado: (2014)

Corrigendum: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay
por: Trypsteen, Wim, et al.
Publicado: (2017)

HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome
por: Baeyens, Ann, et al.
Publicado: (2016)

CD32(+)CD4(+) memory T cells are enriched for total HIV-1 DNA in tissues from humanized mice
por: Adams, Philipp, et al.
Publicado: (2020)

Comparison of digital PCR platforms and semi-nested qPCR as a tool to determine the size of the HIV reservoir
por: Bosman, K. J., et al.
Publicado: (2015)

Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
por: Trypsteen, Wim, et al.
Publicado: (2019)

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells
por: van der Heijden, Wouter A., et al.
Publicado: (2021)

Evaluation of bisulfite kits for DNA methylation profiling in terms of DNA fragmentation and DNA recovery using digital PCR
por: Kint, Sam, et al.
Publicado: (2018)

The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure
por: Kiselinova, Maja, et al.
Publicado: (2016)

PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads
por: Artesi, Maria, et al.
Publicado: (2021)

HIV-1 variants are archived throughout infection and persist in the reservoir
por: Brooks, Kelsie, et al.
Publicado: (2020)

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs
por: Bonczkowski, Pawel, et al.
Publicado: (2014)

Persistence of an intact HIV reservoir in phenotypically naive T cells
por: Venanzi Rullo, Emmanuele, et al.
Publicado: (2020)

Viral and Latent Reservoir Persistence in HIV-1–Infected Patients on Therapy
por: Kim, Hwijin, et al.
Publicado: (2006)

Persistent HIV-1 replication maintains the tissue reservoir during therapy
por: Lorenzo-Redondo, Ramon, et al.
Publicado: (2016)

Monocyte-derived macrophages contain persistent latent HIV reservoirs
por: Veenhuis, Rebecca T., et al.
Publicado: (2023)

Comparison of Methods for In-House Screening of HLA-B*57:01 to Prevent Abacavir Hypersensitivity in HIV-1 Care
por: De Spiegelaere, Ward, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7qlli5nr494hlqkm4m76ebncq7