Cargando…
Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins
Around 350 million people are living with hepatitis B virus (HBV), which can lead to death due to liver cirrhosis and hepatocellular carcinoma (HCC). Various antiviral drugs/nucleot(s)ide analogues are currently used to reduce or arrest the replication of this virus. However, many studies have repor...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077294/ https://www.ncbi.nlm.nih.gov/pubmed/32033216 http://dx.doi.org/10.3390/v12020175 |
_version_ | 1783507400282603520 |
---|---|
author | Hossain, Md. Golzar Akter, Sharmin Ohsaki, Eriko Ueda, Keiji |
author_facet | Hossain, Md. Golzar Akter, Sharmin Ohsaki, Eriko Ueda, Keiji |
author_sort | Hossain, Md. Golzar |
collection | PubMed |
description | Around 350 million people are living with hepatitis B virus (HBV), which can lead to death due to liver cirrhosis and hepatocellular carcinoma (HCC). Various antiviral drugs/nucleot(s)ide analogues are currently used to reduce or arrest the replication of this virus. However, many studies have reported that nucleot(s)ide analogue-resistant HBV is circulating. Cellular signaling pathways could be one of the targets against the viral replication. Several studies reported that viral proteins interacted with mitochondrial proteins and localized in the mitochondria, the powerhouse of the cell. And a recent study showed that mitochondrial turnover induced by thyroid hormones protected hepatocytes from hepatocarcinogenesis mediated by HBV. Strong downregulation of numerous cellular signaling pathways has also been reported to be accompanied by profound mitochondrial alteration, as confirmed by transcriptome profiling of HBV-specific CD8 T cells from chronic and acute HBV patients. In this review, we summarize the ongoing research into mitochondrial proteins and/or signaling involved with HBV proteins, which will continue to provide insight into the relationship between mitochondria and HBV and ultimately lead to advances in viral pathobiology and mitochondria-targeted antiviral therapy. |
format | Online Article Text |
id | pubmed-7077294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70772942020-03-20 Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins Hossain, Md. Golzar Akter, Sharmin Ohsaki, Eriko Ueda, Keiji Viruses Review Around 350 million people are living with hepatitis B virus (HBV), which can lead to death due to liver cirrhosis and hepatocellular carcinoma (HCC). Various antiviral drugs/nucleot(s)ide analogues are currently used to reduce or arrest the replication of this virus. However, many studies have reported that nucleot(s)ide analogue-resistant HBV is circulating. Cellular signaling pathways could be one of the targets against the viral replication. Several studies reported that viral proteins interacted with mitochondrial proteins and localized in the mitochondria, the powerhouse of the cell. And a recent study showed that mitochondrial turnover induced by thyroid hormones protected hepatocytes from hepatocarcinogenesis mediated by HBV. Strong downregulation of numerous cellular signaling pathways has also been reported to be accompanied by profound mitochondrial alteration, as confirmed by transcriptome profiling of HBV-specific CD8 T cells from chronic and acute HBV patients. In this review, we summarize the ongoing research into mitochondrial proteins and/or signaling involved with HBV proteins, which will continue to provide insight into the relationship between mitochondria and HBV and ultimately lead to advances in viral pathobiology and mitochondria-targeted antiviral therapy. MDPI 2020-02-04 /pmc/articles/PMC7077294/ /pubmed/32033216 http://dx.doi.org/10.3390/v12020175 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hossain, Md. Golzar Akter, Sharmin Ohsaki, Eriko Ueda, Keiji Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins |
title | Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins |
title_full | Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins |
title_fullStr | Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins |
title_full_unstemmed | Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins |
title_short | Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins |
title_sort | impact of the interaction of hepatitis b virus with mitochondria and associated proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077294/ https://www.ncbi.nlm.nih.gov/pubmed/32033216 http://dx.doi.org/10.3390/v12020175 |
work_keys_str_mv | AT hossainmdgolzar impactoftheinteractionofhepatitisbviruswithmitochondriaandassociatedproteins AT aktersharmin impactoftheinteractionofhepatitisbviruswithmitochondriaandassociatedproteins AT ohsakieriko impactoftheinteractionofhepatitisbviruswithmitochondriaandassociatedproteins AT uedakeiji impactoftheinteractionofhepatitisbviruswithmitochondriaandassociatedproteins |