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Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus

Zika virus (ZIKV) is a mosquito-borne flavivirus associated with a febrile illness as well as severe complications, including microcephaly and Guillain-Barré Syndrome. Antibody cross-reactivity between flaviviruses has been documented, and in regions where ZIKV is circulating, dengue virus (DENV) is...

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Autores principales: Kozak, Robert A., Goneau, Lee W., DeLima, Cedric, Varsaneux, Olivia, Eshaghi, AliReza, Kristjanson, Erik, Olsha, Romy, Safronetz, David, Perusini, Stephen, Frantz, Christine, Gubbay, Jonathan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077307/
https://www.ncbi.nlm.nih.gov/pubmed/31991674
http://dx.doi.org/10.3390/v12020140
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author Kozak, Robert A.
Goneau, Lee W.
DeLima, Cedric
Varsaneux, Olivia
Eshaghi, AliReza
Kristjanson, Erik
Olsha, Romy
Safronetz, David
Perusini, Stephen
Frantz, Christine
Gubbay, Jonathan B.
author_facet Kozak, Robert A.
Goneau, Lee W.
DeLima, Cedric
Varsaneux, Olivia
Eshaghi, AliReza
Kristjanson, Erik
Olsha, Romy
Safronetz, David
Perusini, Stephen
Frantz, Christine
Gubbay, Jonathan B.
author_sort Kozak, Robert A.
collection PubMed
description Zika virus (ZIKV) is a mosquito-borne flavivirus associated with a febrile illness as well as severe complications, including microcephaly and Guillain-Barré Syndrome. Antibody cross-reactivity between flaviviruses has been documented, and in regions where ZIKV is circulating, dengue virus (DENV) is also endemic, leaving the potential that previous exposure to DENV could alter clinical features of ZIKV infection. To investigate this, we performed a retrospective case-control study in which we compared Canadian travellers who had been infected with ZIKV and had serological findings indicating previous DENV or other flavivirus exposure (n = 16) to those without any previous exposure (n = 44). Patient samples were collected between February 2016 and September 2017 and submitted to Public Health Ontario for testing. ZIKV infection was determined using real-time RT-PCR and antibodies against DENV were identified by the plaque-reduction neutralization test. The mean time from symptom onset to sample collection was 5 days for both groups; the magnitude of viremia was not statistically different (Ct values: 35.6 vs. 34.9, p-value = 0.2). Clinical scores were also similar. Our findings indicate that previous DENV or other flavivirus exposure did not result in greater viremia or a higher illness score.
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spelling pubmed-70773072020-03-20 Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus Kozak, Robert A. Goneau, Lee W. DeLima, Cedric Varsaneux, Olivia Eshaghi, AliReza Kristjanson, Erik Olsha, Romy Safronetz, David Perusini, Stephen Frantz, Christine Gubbay, Jonathan B. Viruses Article Zika virus (ZIKV) is a mosquito-borne flavivirus associated with a febrile illness as well as severe complications, including microcephaly and Guillain-Barré Syndrome. Antibody cross-reactivity between flaviviruses has been documented, and in regions where ZIKV is circulating, dengue virus (DENV) is also endemic, leaving the potential that previous exposure to DENV could alter clinical features of ZIKV infection. To investigate this, we performed a retrospective case-control study in which we compared Canadian travellers who had been infected with ZIKV and had serological findings indicating previous DENV or other flavivirus exposure (n = 16) to those without any previous exposure (n = 44). Patient samples were collected between February 2016 and September 2017 and submitted to Public Health Ontario for testing. ZIKV infection was determined using real-time RT-PCR and antibodies against DENV were identified by the plaque-reduction neutralization test. The mean time from symptom onset to sample collection was 5 days for both groups; the magnitude of viremia was not statistically different (Ct values: 35.6 vs. 34.9, p-value = 0.2). Clinical scores were also similar. Our findings indicate that previous DENV or other flavivirus exposure did not result in greater viremia or a higher illness score. MDPI 2020-01-24 /pmc/articles/PMC7077307/ /pubmed/31991674 http://dx.doi.org/10.3390/v12020140 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kozak, Robert A.
Goneau, Lee W.
DeLima, Cedric
Varsaneux, Olivia
Eshaghi, AliReza
Kristjanson, Erik
Olsha, Romy
Safronetz, David
Perusini, Stephen
Frantz, Christine
Gubbay, Jonathan B.
Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus
title Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus
title_full Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus
title_fullStr Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus
title_full_unstemmed Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus
title_short Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus
title_sort presence of flavivirus antibodies does not lead to a greater number of symptoms in a small cohort of canadian travelers infected with zika virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077307/
https://www.ncbi.nlm.nih.gov/pubmed/31991674
http://dx.doi.org/10.3390/v12020140
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