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Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus
Zika virus (ZIKV) is a mosquito-borne flavivirus associated with a febrile illness as well as severe complications, including microcephaly and Guillain-Barré Syndrome. Antibody cross-reactivity between flaviviruses has been documented, and in regions where ZIKV is circulating, dengue virus (DENV) is...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077307/ https://www.ncbi.nlm.nih.gov/pubmed/31991674 http://dx.doi.org/10.3390/v12020140 |
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author | Kozak, Robert A. Goneau, Lee W. DeLima, Cedric Varsaneux, Olivia Eshaghi, AliReza Kristjanson, Erik Olsha, Romy Safronetz, David Perusini, Stephen Frantz, Christine Gubbay, Jonathan B. |
author_facet | Kozak, Robert A. Goneau, Lee W. DeLima, Cedric Varsaneux, Olivia Eshaghi, AliReza Kristjanson, Erik Olsha, Romy Safronetz, David Perusini, Stephen Frantz, Christine Gubbay, Jonathan B. |
author_sort | Kozak, Robert A. |
collection | PubMed |
description | Zika virus (ZIKV) is a mosquito-borne flavivirus associated with a febrile illness as well as severe complications, including microcephaly and Guillain-Barré Syndrome. Antibody cross-reactivity between flaviviruses has been documented, and in regions where ZIKV is circulating, dengue virus (DENV) is also endemic, leaving the potential that previous exposure to DENV could alter clinical features of ZIKV infection. To investigate this, we performed a retrospective case-control study in which we compared Canadian travellers who had been infected with ZIKV and had serological findings indicating previous DENV or other flavivirus exposure (n = 16) to those without any previous exposure (n = 44). Patient samples were collected between February 2016 and September 2017 and submitted to Public Health Ontario for testing. ZIKV infection was determined using real-time RT-PCR and antibodies against DENV were identified by the plaque-reduction neutralization test. The mean time from symptom onset to sample collection was 5 days for both groups; the magnitude of viremia was not statistically different (Ct values: 35.6 vs. 34.9, p-value = 0.2). Clinical scores were also similar. Our findings indicate that previous DENV or other flavivirus exposure did not result in greater viremia or a higher illness score. |
format | Online Article Text |
id | pubmed-7077307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70773072020-03-20 Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus Kozak, Robert A. Goneau, Lee W. DeLima, Cedric Varsaneux, Olivia Eshaghi, AliReza Kristjanson, Erik Olsha, Romy Safronetz, David Perusini, Stephen Frantz, Christine Gubbay, Jonathan B. Viruses Article Zika virus (ZIKV) is a mosquito-borne flavivirus associated with a febrile illness as well as severe complications, including microcephaly and Guillain-Barré Syndrome. Antibody cross-reactivity between flaviviruses has been documented, and in regions where ZIKV is circulating, dengue virus (DENV) is also endemic, leaving the potential that previous exposure to DENV could alter clinical features of ZIKV infection. To investigate this, we performed a retrospective case-control study in which we compared Canadian travellers who had been infected with ZIKV and had serological findings indicating previous DENV or other flavivirus exposure (n = 16) to those without any previous exposure (n = 44). Patient samples were collected between February 2016 and September 2017 and submitted to Public Health Ontario for testing. ZIKV infection was determined using real-time RT-PCR and antibodies against DENV were identified by the plaque-reduction neutralization test. The mean time from symptom onset to sample collection was 5 days for both groups; the magnitude of viremia was not statistically different (Ct values: 35.6 vs. 34.9, p-value = 0.2). Clinical scores were also similar. Our findings indicate that previous DENV or other flavivirus exposure did not result in greater viremia or a higher illness score. MDPI 2020-01-24 /pmc/articles/PMC7077307/ /pubmed/31991674 http://dx.doi.org/10.3390/v12020140 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kozak, Robert A. Goneau, Lee W. DeLima, Cedric Varsaneux, Olivia Eshaghi, AliReza Kristjanson, Erik Olsha, Romy Safronetz, David Perusini, Stephen Frantz, Christine Gubbay, Jonathan B. Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus |
title | Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus |
title_full | Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus |
title_fullStr | Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus |
title_full_unstemmed | Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus |
title_short | Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus |
title_sort | presence of flavivirus antibodies does not lead to a greater number of symptoms in a small cohort of canadian travelers infected with zika virus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077307/ https://www.ncbi.nlm.nih.gov/pubmed/31991674 http://dx.doi.org/10.3390/v12020140 |
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