Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan

The A(H1N1)pdm09 virus emerged in 2009 and continues to circulate in human populations. Recent A(H1N1)pdm09 viruses, that is, A(H1N1)pdm09 viruses circulating in the post-pandemic era, can cause more or less severe infections than those caused by the initial pandemic viruses. To evaluate the changes...

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Autores principales: Mitake, Hiromichi, Yasuhara, Atsuhiro, Lopes, Tiago J. S., Tagawa-Sakai, Yuko, Shimizu, Kohei, Ozawa, Hiroki, Kawakami, Chiharu, Morikawa, Saeko, Sugaya, Norio, Watanabe, Tokiko, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077310/
https://www.ncbi.nlm.nih.gov/pubmed/32013144
http://dx.doi.org/10.3390/v12020155
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author Mitake, Hiromichi
Yasuhara, Atsuhiro
Lopes, Tiago J. S.
Tagawa-Sakai, Yuko
Shimizu, Kohei
Ozawa, Hiroki
Kawakami, Chiharu
Morikawa, Saeko
Sugaya, Norio
Watanabe, Tokiko
Kawaoka, Yoshihiro
author_facet Mitake, Hiromichi
Yasuhara, Atsuhiro
Lopes, Tiago J. S.
Tagawa-Sakai, Yuko
Shimizu, Kohei
Ozawa, Hiroki
Kawakami, Chiharu
Morikawa, Saeko
Sugaya, Norio
Watanabe, Tokiko
Kawaoka, Yoshihiro
author_sort Mitake, Hiromichi
collection PubMed
description The A(H1N1)pdm09 virus emerged in 2009 and continues to circulate in human populations. Recent A(H1N1)pdm09 viruses, that is, A(H1N1)pdm09 viruses circulating in the post-pandemic era, can cause more or less severe infections than those caused by the initial pandemic viruses. To evaluate the changes in pathogenicity of the A(H1N1)pdm09 viruses during their continued circulation in humans, we compared the nucleotide and amino acid sequences of ten A(H1N1)pdm09 viruses isolated in Japan between 2009 and 2015, and experimentally infected mice with each virus. The severity of infection caused by these Japanese isolates ranged from milder to more severe than that caused by the prototypic pandemic strain A/California/04/2009 (CA04/09); however, specific mutations responsible for their pathogenicity have not yet been identified.
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spelling pubmed-70773102020-03-20 Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan Mitake, Hiromichi Yasuhara, Atsuhiro Lopes, Tiago J. S. Tagawa-Sakai, Yuko Shimizu, Kohei Ozawa, Hiroki Kawakami, Chiharu Morikawa, Saeko Sugaya, Norio Watanabe, Tokiko Kawaoka, Yoshihiro Viruses Article The A(H1N1)pdm09 virus emerged in 2009 and continues to circulate in human populations. Recent A(H1N1)pdm09 viruses, that is, A(H1N1)pdm09 viruses circulating in the post-pandemic era, can cause more or less severe infections than those caused by the initial pandemic viruses. To evaluate the changes in pathogenicity of the A(H1N1)pdm09 viruses during their continued circulation in humans, we compared the nucleotide and amino acid sequences of ten A(H1N1)pdm09 viruses isolated in Japan between 2009 and 2015, and experimentally infected mice with each virus. The severity of infection caused by these Japanese isolates ranged from milder to more severe than that caused by the prototypic pandemic strain A/California/04/2009 (CA04/09); however, specific mutations responsible for their pathogenicity have not yet been identified. MDPI 2020-01-29 /pmc/articles/PMC7077310/ /pubmed/32013144 http://dx.doi.org/10.3390/v12020155 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mitake, Hiromichi
Yasuhara, Atsuhiro
Lopes, Tiago J. S.
Tagawa-Sakai, Yuko
Shimizu, Kohei
Ozawa, Hiroki
Kawakami, Chiharu
Morikawa, Saeko
Sugaya, Norio
Watanabe, Tokiko
Kawaoka, Yoshihiro
Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan
title Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan
title_full Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan
title_fullStr Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan
title_full_unstemmed Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan
title_short Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan
title_sort comparison of the pathogenicity in mice of a(h1n1)pdm09 viruses isolated between 2009 and 2015 in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077310/
https://www.ncbi.nlm.nih.gov/pubmed/32013144
http://dx.doi.org/10.3390/v12020155
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