Host Transcription Factors in Hepatitis B Virus RNA Synthesis

The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the n...

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Autores principales: Turton, Kristi L., Meier-Stephenson, Vanessa, Badmalia, Maulik D., Coffin, Carla S., Patel, Trushar R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077322/
https://www.ncbi.nlm.nih.gov/pubmed/32019103
http://dx.doi.org/10.3390/v12020160
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author Turton, Kristi L.
Meier-Stephenson, Vanessa
Badmalia, Maulik D.
Coffin, Carla S.
Patel, Trushar R.
author_facet Turton, Kristi L.
Meier-Stephenson, Vanessa
Badmalia, Maulik D.
Coffin, Carla S.
Patel, Trushar R.
author_sort Turton, Kristi L.
collection PubMed
description The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the nucleus. As HBV replication requires the help of host transcription factors to replicate, focusing on host protein–HBV genome interactions may reveal insights into new drug targets against cccDNA. The structural details on such complexes, however, remain poorly defined. In this review, the current literature regarding host transcription factors’ interactions with HBV cccDNA is discussed.
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spelling pubmed-70773222020-03-20 Host Transcription Factors in Hepatitis B Virus RNA Synthesis Turton, Kristi L. Meier-Stephenson, Vanessa Badmalia, Maulik D. Coffin, Carla S. Patel, Trushar R. Viruses Review The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the nucleus. As HBV replication requires the help of host transcription factors to replicate, focusing on host protein–HBV genome interactions may reveal insights into new drug targets against cccDNA. The structural details on such complexes, however, remain poorly defined. In this review, the current literature regarding host transcription factors’ interactions with HBV cccDNA is discussed. MDPI 2020-01-30 /pmc/articles/PMC7077322/ /pubmed/32019103 http://dx.doi.org/10.3390/v12020160 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Turton, Kristi L.
Meier-Stephenson, Vanessa
Badmalia, Maulik D.
Coffin, Carla S.
Patel, Trushar R.
Host Transcription Factors in Hepatitis B Virus RNA Synthesis
title Host Transcription Factors in Hepatitis B Virus RNA Synthesis
title_full Host Transcription Factors in Hepatitis B Virus RNA Synthesis
title_fullStr Host Transcription Factors in Hepatitis B Virus RNA Synthesis
title_full_unstemmed Host Transcription Factors in Hepatitis B Virus RNA Synthesis
title_short Host Transcription Factors in Hepatitis B Virus RNA Synthesis
title_sort host transcription factors in hepatitis b virus rna synthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077322/
https://www.ncbi.nlm.nih.gov/pubmed/32019103
http://dx.doi.org/10.3390/v12020160
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