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Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s

Electrospinning and post-spun conformations of hydrophobic poly(α-amino acid)s are described in this study. The poly(α-amino acid)s, poly(Gly), poly(l-Ala), poly(l-Val), and poly(l-Leu) were synthesized via corresponding N-carboxy-α-amino acid anhydrides. The average molecular weight and degree of p...

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Autores principales: Devarayan, Kesavan, Nakagami, Souta, Suzuki, Shuichi, Yuki, Ichiro, Ohkawa, Kousaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077440/
https://www.ncbi.nlm.nih.gov/pubmed/32033154
http://dx.doi.org/10.3390/polym12020327
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author Devarayan, Kesavan
Nakagami, Souta
Suzuki, Shuichi
Yuki, Ichiro
Ohkawa, Kousaku
author_facet Devarayan, Kesavan
Nakagami, Souta
Suzuki, Shuichi
Yuki, Ichiro
Ohkawa, Kousaku
author_sort Devarayan, Kesavan
collection PubMed
description Electrospinning and post-spun conformations of hydrophobic poly(α-amino acid)s are described in this study. The poly(α-amino acid)s, poly(Gly), poly(l-Ala), poly(l-Val), and poly(l-Leu) were synthesized via corresponding N-carboxy-α-amino acid anhydrides. The average molecular weight and degree of polymerization of these polymers were determined by N-terminus labeling using 2,4-dinitrofluorobenzene and by viscometry in the case of poly(Gly). These poly(α-amino acid)s were electrospun from trifluoroacetic acid or trifluoroacetic acid/dichloromethane solutions. The FT-IR spectroscopy and wide-angle X-ray diffraction indicated that the electrospun poly(l-Ala) and poly(l-Leu) fibers predominantly adopts α-helical structure, whereas poly(l-Val) and poly(Gly) fibers exhibited mainly β-strand and random coil structures, respectively.
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spelling pubmed-70774402020-03-20 Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s Devarayan, Kesavan Nakagami, Souta Suzuki, Shuichi Yuki, Ichiro Ohkawa, Kousaku Polymers (Basel) Article Electrospinning and post-spun conformations of hydrophobic poly(α-amino acid)s are described in this study. The poly(α-amino acid)s, poly(Gly), poly(l-Ala), poly(l-Val), and poly(l-Leu) were synthesized via corresponding N-carboxy-α-amino acid anhydrides. The average molecular weight and degree of polymerization of these polymers were determined by N-terminus labeling using 2,4-dinitrofluorobenzene and by viscometry in the case of poly(Gly). These poly(α-amino acid)s were electrospun from trifluoroacetic acid or trifluoroacetic acid/dichloromethane solutions. The FT-IR spectroscopy and wide-angle X-ray diffraction indicated that the electrospun poly(l-Ala) and poly(l-Leu) fibers predominantly adopts α-helical structure, whereas poly(l-Val) and poly(Gly) fibers exhibited mainly β-strand and random coil structures, respectively. MDPI 2020-02-04 /pmc/articles/PMC7077440/ /pubmed/32033154 http://dx.doi.org/10.3390/polym12020327 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Devarayan, Kesavan
Nakagami, Souta
Suzuki, Shuichi
Yuki, Ichiro
Ohkawa, Kousaku
Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s
title Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s
title_full Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s
title_fullStr Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s
title_full_unstemmed Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s
title_short Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s
title_sort electrospinning and post-spun chain conformations of synthetic, hydrophobic poly(α-amino acid)s
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077440/
https://www.ncbi.nlm.nih.gov/pubmed/32033154
http://dx.doi.org/10.3390/polym12020327
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