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Evaluation of Electrocardiographic Ventricular Depolarization and Repolarization Variables in Type 1 Diabetes Mellitus
BACKGROUND: The risk of cardiovascular events and sudden death increases with type 1 diabetes mellitus (T1DM). OBJECTIVE: To evaluate electrocardiographic markers of arrhythmias in T1DM patients. METHODS: Electrocardiographic parameters reflecting ventricular depolarization and repolarization, namel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia - SBC
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077569/ https://www.ncbi.nlm.nih.gov/pubmed/32215498 http://dx.doi.org/10.36660/abc.20180343 |
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author | Inanır, Mehmet Gunes, Yilmaz Sincer, Isa Erdal, Emrah |
author_facet | Inanır, Mehmet Gunes, Yilmaz Sincer, Isa Erdal, Emrah |
author_sort | Inanır, Mehmet |
collection | PubMed |
description | BACKGROUND: The risk of cardiovascular events and sudden death increases with type 1 diabetes mellitus (T1DM). OBJECTIVE: To evaluate electrocardiographic markers of arrhythmias in T1DM patients. METHODS: Electrocardiographic parameters reflecting ventricular depolarization and repolarization, namely, QT, QTc, QTd, QTdc, Tp-e, JT, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios, of 46 patients diagnosed with T1DM were retrospectively analyzed and compared with 46 healthy age-, sex-, and body mass-matched controls. Correlations between T1DM duration, hemoglobin A1c (HbA1c), and ventricular repolarization variables were analyzed. P values lower than 0.05 were considered statistically significant. RESULTS: Diabetes duration was 16.6 ± 7.1 years, and HbA1c was 10.81% ± 3.27% in the T1DM group. In comparison with the control group, heart rate, QTc, QTd, QTdc, Tp-e and JTc intervals, Tp-e/QT ratio (p < 0.001), and Tp-e/QTc ratio (p = 0.007) were significantly higher in T1DM patients. T1DM duration and HbA1c levels were significantly correlated with QTc, QTd, QTdc, Tp-e, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios. CONCLUSIONS: In T1DM patients, potential electrocardiographic repolarization predictors were significantly increased in correlation with disease duration and HbA1c levels. These findings may contribute to the understanding of sudden cardiac death in patients with T1DM. |
format | Online Article Text |
id | pubmed-7077569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedade Brasileira de Cardiologia - SBC |
record_format | MEDLINE/PubMed |
spelling | pubmed-70775692020-03-18 Evaluation of Electrocardiographic Ventricular Depolarization and Repolarization Variables in Type 1 Diabetes Mellitus Inanır, Mehmet Gunes, Yilmaz Sincer, Isa Erdal, Emrah Arq Bras Cardiol Original Article BACKGROUND: The risk of cardiovascular events and sudden death increases with type 1 diabetes mellitus (T1DM). OBJECTIVE: To evaluate electrocardiographic markers of arrhythmias in T1DM patients. METHODS: Electrocardiographic parameters reflecting ventricular depolarization and repolarization, namely, QT, QTc, QTd, QTdc, Tp-e, JT, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios, of 46 patients diagnosed with T1DM were retrospectively analyzed and compared with 46 healthy age-, sex-, and body mass-matched controls. Correlations between T1DM duration, hemoglobin A1c (HbA1c), and ventricular repolarization variables were analyzed. P values lower than 0.05 were considered statistically significant. RESULTS: Diabetes duration was 16.6 ± 7.1 years, and HbA1c was 10.81% ± 3.27% in the T1DM group. In comparison with the control group, heart rate, QTc, QTd, QTdc, Tp-e and JTc intervals, Tp-e/QT ratio (p < 0.001), and Tp-e/QTc ratio (p = 0.007) were significantly higher in T1DM patients. T1DM duration and HbA1c levels were significantly correlated with QTc, QTd, QTdc, Tp-e, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios. CONCLUSIONS: In T1DM patients, potential electrocardiographic repolarization predictors were significantly increased in correlation with disease duration and HbA1c levels. These findings may contribute to the understanding of sudden cardiac death in patients with T1DM. Sociedade Brasileira de Cardiologia - SBC 2020-02 /pmc/articles/PMC7077569/ /pubmed/32215498 http://dx.doi.org/10.36660/abc.20180343 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Inanır, Mehmet Gunes, Yilmaz Sincer, Isa Erdal, Emrah Evaluation of Electrocardiographic Ventricular Depolarization and Repolarization Variables in Type 1 Diabetes Mellitus |
title | Evaluation of Electrocardiographic Ventricular Depolarization and Repolarization Variables in Type 1 Diabetes Mellitus |
title_full | Evaluation of Electrocardiographic Ventricular Depolarization and Repolarization Variables in Type 1 Diabetes Mellitus |
title_fullStr | Evaluation of Electrocardiographic Ventricular Depolarization and Repolarization Variables in Type 1 Diabetes Mellitus |
title_full_unstemmed | Evaluation of Electrocardiographic Ventricular Depolarization and Repolarization Variables in Type 1 Diabetes Mellitus |
title_short | Evaluation of Electrocardiographic Ventricular Depolarization and Repolarization Variables in Type 1 Diabetes Mellitus |
title_sort | evaluation of electrocardiographic ventricular depolarization and repolarization variables in type 1 diabetes mellitus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077569/ https://www.ncbi.nlm.nih.gov/pubmed/32215498 http://dx.doi.org/10.36660/abc.20180343 |
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