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Doubly Dynamic Hydrogel Formed by Combining Boronate Ester and Acylhydrazone Bonds

The incorporation of double dynamic bonds into hydrogels provides an effective strategy to engineer their performance on demand. Herein, novel hydrogels were PREPARED by combining two kinetically distinct dynamic covalent bonds, boronate ester and acylhydrazone bonds, and the synergistic properties...

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Autores principales: Liu, Yusheng, Liu, Yigang, Wang, Qiuxia, Han, Yugui, Chen, Hao, Tan, Yebang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077654/
https://www.ncbi.nlm.nih.gov/pubmed/32098242
http://dx.doi.org/10.3390/polym12020487
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author Liu, Yusheng
Liu, Yigang
Wang, Qiuxia
Han, Yugui
Chen, Hao
Tan, Yebang
author_facet Liu, Yusheng
Liu, Yigang
Wang, Qiuxia
Han, Yugui
Chen, Hao
Tan, Yebang
author_sort Liu, Yusheng
collection PubMed
description The incorporation of double dynamic bonds into hydrogels provides an effective strategy to engineer their performance on demand. Herein, novel hydrogels were PREPARED by combining two kinetically distinct dynamic covalent bonds, boronate ester and acylhydrazone bonds, and the synergistic properties of the hydrogels were studied comprehensively. The functional diblock copolymers P(N-isopropyl acrylamide-co-N-acryloyl-3-aminophenylboronic acid)-b-(N-isopropyl acrylamide-co-diacetone acrylamide) (PAD) were prepared via reversible addition−fragmentation chain transfer (RAFT) polymerization. The hydrogel was constructed by exploiting dynamic reaction of phenyboronic acid moieties with polyvinyl alcohol (PVA) and ketone moieties with adipic dihydrazide (ADH) without any catalyst. The active boronate ester linkage endows the hydrogel with fast gelation kinetics and self-healing ability, and the stable acylhydrazone linkage can enhance the mechanical property of the hydrogel. The difference in kinetics endows that the contribution of each linkage to mechanical strength of the hydrogel can be accurately estimated. Moreover, the mechanical property of the hydrogel can be readily engineered by changing the composition and solid content, as well as by controlling the formation or dissociation of the dynamic linkages. Thus, we provide a promising strategy to design and prepare multi-responsive hydrogels with tunable properties.
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spelling pubmed-70776542020-03-20 Doubly Dynamic Hydrogel Formed by Combining Boronate Ester and Acylhydrazone Bonds Liu, Yusheng Liu, Yigang Wang, Qiuxia Han, Yugui Chen, Hao Tan, Yebang Polymers (Basel) Article The incorporation of double dynamic bonds into hydrogels provides an effective strategy to engineer their performance on demand. Herein, novel hydrogels were PREPARED by combining two kinetically distinct dynamic covalent bonds, boronate ester and acylhydrazone bonds, and the synergistic properties of the hydrogels were studied comprehensively. The functional diblock copolymers P(N-isopropyl acrylamide-co-N-acryloyl-3-aminophenylboronic acid)-b-(N-isopropyl acrylamide-co-diacetone acrylamide) (PAD) were prepared via reversible addition−fragmentation chain transfer (RAFT) polymerization. The hydrogel was constructed by exploiting dynamic reaction of phenyboronic acid moieties with polyvinyl alcohol (PVA) and ketone moieties with adipic dihydrazide (ADH) without any catalyst. The active boronate ester linkage endows the hydrogel with fast gelation kinetics and self-healing ability, and the stable acylhydrazone linkage can enhance the mechanical property of the hydrogel. The difference in kinetics endows that the contribution of each linkage to mechanical strength of the hydrogel can be accurately estimated. Moreover, the mechanical property of the hydrogel can be readily engineered by changing the composition and solid content, as well as by controlling the formation or dissociation of the dynamic linkages. Thus, we provide a promising strategy to design and prepare multi-responsive hydrogels with tunable properties. MDPI 2020-02-21 /pmc/articles/PMC7077654/ /pubmed/32098242 http://dx.doi.org/10.3390/polym12020487 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Yusheng
Liu, Yigang
Wang, Qiuxia
Han, Yugui
Chen, Hao
Tan, Yebang
Doubly Dynamic Hydrogel Formed by Combining Boronate Ester and Acylhydrazone Bonds
title Doubly Dynamic Hydrogel Formed by Combining Boronate Ester and Acylhydrazone Bonds
title_full Doubly Dynamic Hydrogel Formed by Combining Boronate Ester and Acylhydrazone Bonds
title_fullStr Doubly Dynamic Hydrogel Formed by Combining Boronate Ester and Acylhydrazone Bonds
title_full_unstemmed Doubly Dynamic Hydrogel Formed by Combining Boronate Ester and Acylhydrazone Bonds
title_short Doubly Dynamic Hydrogel Formed by Combining Boronate Ester and Acylhydrazone Bonds
title_sort doubly dynamic hydrogel formed by combining boronate ester and acylhydrazone bonds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077654/
https://www.ncbi.nlm.nih.gov/pubmed/32098242
http://dx.doi.org/10.3390/polym12020487
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