Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity

The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epitopes. How the level of diversity within the memor...

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Detalles Bibliográficos
Autores principales: Kavazović, Inga, Han, Hongya, Balzaretti, Giulia, Slinger, Erik, Lemmermann, Niels A. W., ten Brinke, Anja, Merkler, Doron, Koster, Jan, Bryceson, Yenan T., de Vries, Niek, Jonjić, Stipan, Klarenbeek, Paul L., Polić, Bojan, Eldering, Eric, Wensveen, Felix M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077837/
https://www.ncbi.nlm.nih.gov/pubmed/32182234
http://dx.doi.org/10.1371/journal.pbio.3000648

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