Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

Although acute melioidosis is the most common outcome of Burkholderia pseudomallei infection, we have documented a case, P314, where disease severity lessened with time, and the pathogen evolved towards a commensal relationship with the host. In the current study, we used whole-genome sequencing to...

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Detalles Bibliográficos
Autores principales: Pearson, Talima, Sahl, Jason W., Hepp, Crystal M., Handady, Karthik, Hornstra, Heidie, Vazquez, Adam J., Settles, Erik, Mayo, Mark, Kaestli, Mirjam, Williamson, Charles H. D., Price, Erin P., Sarovich, Derek S., Cook, James M., Wolken, Spenser R., Bowen, Richard A., Tuanyok, Apichai, Foster, Jeffrey T., Drees, Kevin P., Kidd, Timothy J., Bell, Scott C., Currie, Bart J., Keim, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077878/
https://www.ncbi.nlm.nih.gov/pubmed/32134991
http://dx.doi.org/10.1371/journal.ppat.1008298

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