Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia

Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the poten...

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Detalles Bibliográficos
Autores principales: Bai, Xinyue, Yang, Xian-Jie, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077977/
https://www.ncbi.nlm.nih.gov/pubmed/31376721
http://dx.doi.org/10.1016/j.scr.2019.101495
Descripción
Sumario:Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM.

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