Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia

Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the poten...

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Autores principales: Bai, Xinyue, Yang, Xian-Jie, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077977/
https://www.ncbi.nlm.nih.gov/pubmed/31376721
http://dx.doi.org/10.1016/j.scr.2019.101495
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author Bai, Xinyue
Yang, Xian-Jie
Chen, Ling
author_facet Bai, Xinyue
Yang, Xian-Jie
Chen, Ling
author_sort Bai, Xinyue
collection PubMed
description Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM.
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spelling pubmed-70779772020-03-17 Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia Bai, Xinyue Yang, Xian-Jie Chen, Ling Stem Cell Res Article Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM. 2019-07-09 2019-08 /pmc/articles/PMC7077977/ /pubmed/31376721 http://dx.doi.org/10.1016/j.scr.2019.101495 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Bai, Xinyue
Yang, Xian-Jie
Chen, Ling
Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia
title Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia
title_full Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia
title_fullStr Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia
title_full_unstemmed Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia
title_short Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia
title_sort generation of an integration-free induced pluripotent stem cell line (fdeenti003-a) from a patient with pathological myopia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077977/
https://www.ncbi.nlm.nih.gov/pubmed/31376721
http://dx.doi.org/10.1016/j.scr.2019.101495
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AT chenling generationofanintegrationfreeinducedpluripotentstemcelllinefdeenti003afromapatientwithpathologicalmyopia

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