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Wikidata as a knowledge graph for the life sciences

Wikidata is a community-maintained knowledge base that has been assembled from repositories in the fields of genomics, proteomics, genetic variants, pathways, chemical compounds, and diseases, and that adheres to the FAIR principles of findability, accessibility, interoperability and reusability. He...

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Detalles Bibliográficos
Autores principales: Waagmeester, Andra, Stupp, Gregory, Burgstaller-Muehlbacher, Sebastian, Good, Benjamin M, Griffith, Malachi, Griffith, Obi L, Hanspers, Kristina, Hermjakob, Henning, Hudson, Toby S, Hybiske, Kevin, Keating, Sarah M, Manske, Magnus, Mayers, Michael, Mietchen, Daniel, Mitraka, Elvira, Pico, Alexander R, Putman, Timothy, Riutta, Anders, Queralt-Rosinach, Nuria, Schriml, Lynn M, Shafee, Thomas, Slenter, Denise, Stephan, Ralf, Thornton, Katherine, Tsueng, Ginger, Tu, Roger, Ul-Hasan, Sabah, Willighagen, Egon, Wu, Chunlei, Su, Andrew I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077981/
https://www.ncbi.nlm.nih.gov/pubmed/32180547
http://dx.doi.org/10.7554/eLife.52614
Descripción
Sumario:Wikidata is a community-maintained knowledge base that has been assembled from repositories in the fields of genomics, proteomics, genetic variants, pathways, chemical compounds, and diseases, and that adheres to the FAIR principles of findability, accessibility, interoperability and reusability. Here we describe the breadth and depth of the biomedical knowledge contained within Wikidata, and discuss the open-source tools we have built to add information to Wikidata and to synchronize it with source databases. We also demonstrate several use cases for Wikidata, including the crowdsourced curation of biomedical ontologies, phenotype-based diagnosis of disease, and drug repurposing.