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Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme

The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was discovered that catalyzes the dehydration of Hyp to...

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Detalles Bibliográficos
Autores principales:	Backman, Lindsey RF, Huang, Yolanda Y, Andorfer, Mary C, Gold, Brian, Raines, Ronald T, Balskus, Emily P, Drennan, Catherine L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077986/ https://www.ncbi.nlm.nih.gov/pubmed/32180548 http://dx.doi.org/10.7554/eLife.51420

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