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The Reliability of Histamine Pharmacodynamic Response Phenotype Classification in Children With Allergic Disease

We have identified distinct histamine pharmacodynamic response phenotypes in children with allergic disease utilizing histamine iontophoresis with laser Doppler (HILD). These response phenotypes may be relevant in guiding therapeutic decision making for agents targeting the allergic response pathway...

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Autores principales: Kumar, Shaun S., Liu, Xiaoxi, Sherwin, Catherine M., Jones, Bridgette L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078102/
https://www.ncbi.nlm.nih.gov/pubmed/32218731
http://dx.doi.org/10.3389/fphar.2020.00227
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author Kumar, Shaun S.
Liu, Xiaoxi
Sherwin, Catherine M.
Jones, Bridgette L.
author_facet Kumar, Shaun S.
Liu, Xiaoxi
Sherwin, Catherine M.
Jones, Bridgette L.
author_sort Kumar, Shaun S.
collection PubMed
description We have identified distinct histamine pharmacodynamic response phenotypes in children with allergic disease utilizing histamine iontophoresis with laser Doppler (HILD). These response phenotypes may be relevant in guiding therapeutic decision making for agents targeting the allergic response pathways. However, the reliability of these response phenotypes has not been assessed. Therefore, we performed HILD in children with allergic rhinitis and/or asthma on two to three separate occasions. HILD response-time data were analyzed in NONMEM using a linked effect PKPD model. Examination of observed vs. classified response phenotypes predicted response plots and the sum of residuals. The intraclass correlation coefficient (ICC) was used to determine the reliability of phenotype classification. Eighty-two percent of children exhibited a reliable histamine response phenotype [intraclass correlation coefficient 0.77 (95% CI 0.44–0.93]. These preliminary results suggest moderate reliability of HILD response phenotype in children. Further exploration is needed to determine contributions to phenotype variability.
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spelling pubmed-70781022020-03-26 The Reliability of Histamine Pharmacodynamic Response Phenotype Classification in Children With Allergic Disease Kumar, Shaun S. Liu, Xiaoxi Sherwin, Catherine M. Jones, Bridgette L. Front Pharmacol Pharmacology We have identified distinct histamine pharmacodynamic response phenotypes in children with allergic disease utilizing histamine iontophoresis with laser Doppler (HILD). These response phenotypes may be relevant in guiding therapeutic decision making for agents targeting the allergic response pathways. However, the reliability of these response phenotypes has not been assessed. Therefore, we performed HILD in children with allergic rhinitis and/or asthma on two to three separate occasions. HILD response-time data were analyzed in NONMEM using a linked effect PKPD model. Examination of observed vs. classified response phenotypes predicted response plots and the sum of residuals. The intraclass correlation coefficient (ICC) was used to determine the reliability of phenotype classification. Eighty-two percent of children exhibited a reliable histamine response phenotype [intraclass correlation coefficient 0.77 (95% CI 0.44–0.93]. These preliminary results suggest moderate reliability of HILD response phenotype in children. Further exploration is needed to determine contributions to phenotype variability. Frontiers Media S.A. 2020-03-11 /pmc/articles/PMC7078102/ /pubmed/32218731 http://dx.doi.org/10.3389/fphar.2020.00227 Text en Copyright © 2020 Kumar, Liu, Sherwin and Jones. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kumar, Shaun S.
Liu, Xiaoxi
Sherwin, Catherine M.
Jones, Bridgette L.
The Reliability of Histamine Pharmacodynamic Response Phenotype Classification in Children With Allergic Disease
title The Reliability of Histamine Pharmacodynamic Response Phenotype Classification in Children With Allergic Disease
title_full The Reliability of Histamine Pharmacodynamic Response Phenotype Classification in Children With Allergic Disease
title_fullStr The Reliability of Histamine Pharmacodynamic Response Phenotype Classification in Children With Allergic Disease
title_full_unstemmed The Reliability of Histamine Pharmacodynamic Response Phenotype Classification in Children With Allergic Disease
title_short The Reliability of Histamine Pharmacodynamic Response Phenotype Classification in Children With Allergic Disease
title_sort reliability of histamine pharmacodynamic response phenotype classification in children with allergic disease
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078102/
https://www.ncbi.nlm.nih.gov/pubmed/32218731
http://dx.doi.org/10.3389/fphar.2020.00227
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