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Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis

Although fibrosis depicts a reparative mechanism, maladaptation of the heart due to excessive production of extracellular matrix accelerates cardiac dysfunction. The anthraquinone Rhein was examined for its anti-fibrotic potency to mitigate cardiac fibroblast-to-myofibroblast transition (FMT). Prima...

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Detalles Bibliográficos
Autores principales:	Barbosa, David Monteiro, Fahlbusch, Pia, Herzfeld de Wiza, Daniella, Jacob, Sylvia, Kettel, Ulrike, Al-Hasani, Hadi, Krüger, Martina, Ouwens, D. Margriet, Hartwig, Sonja, Lehr, Stefan, Kotzka, Jorg, Knebel, Birgit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078222/ https://www.ncbi.nlm.nih.gov/pubmed/32184434 http://dx.doi.org/10.1038/s41598-020-61886-3

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