Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

The kinase mTOR complex 1 (mTORC1) promotes cellular growth and is frequently dysregulated in cancers. In response to nutrients, mTORC1 is activated on lysosomes by Rag and Rheb guanosine triphosphatases (GTPases) and drives biosynthetic processes. How limitations in nutrients suppress mTORC1 activi...

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Detalles Bibliográficos
Autores principales: Mutvei, Anders P., Nagiec, Michal J., Hamann, Jens C., Kim, Sang Gyun, Vincent, C. Theresa, Blenis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078236/
https://www.ncbi.nlm.nih.gov/pubmed/32184389
http://dx.doi.org/10.1038/s41467-020-15156-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078236/
https://www.ncbi.nlm.nih.gov/pubmed/32184389
http://dx.doi.org/10.1038/s41467-020-15156-5

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