Specific, reversible G1 arrest by UCN-01 in vivo provides cytostatic protection of normal cells against cytotoxic chemotherapy in breast cancer

BACKGROUND: Low-dose UCN-01 mediates G1 arrest in normal proliferating cell lines with an intact G1 to S transition but not tumour cells with a deregulated G1 to S checkpoint. Here we hypothesised that UCN-01 is effective in mediating a selective, reversible G1 arrest of normal proliferating cells,...

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Detalles Bibliográficos
Autores principales: Mull, Benjamin B., Livingston, J. Andrew, Patel, Nalini, Bui, Tuyen, Hunt, Kelly K., Keyomarsi, Khandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078276/
https://www.ncbi.nlm.nih.gov/pubmed/31942030
http://dx.doi.org/10.1038/s41416-019-0707-z

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