Optimized Assessment of qPCR-Based Vector Copy Numbers as a Safety Parameter for GMP-Grade CAR T Cells and Monitoring of Frequency in Patients

Chimeric antigen receptor (CAR) T cells are considered genetically modified organisms (GMOs) and constitute gene therapy medicinal products. Thus, CAR T cell manufacturing for clinical application is strictly regulated. Appropriate methods to assess vector copy numbers (VCNs) in CAR T cell products...

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Detalles Bibliográficos
Autores principales: Kunz, Alexander, Gern, Ulrike, Schmitt, Anita, Neuber, Brigitte, Wang, Lei, Hückelhoven-Krauss, Angela, Michels, Birgit, Hofmann, Susanne, Müller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael, Schubert, Maria-Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078460/
https://www.ncbi.nlm.nih.gov/pubmed/32201711
http://dx.doi.org/10.1016/j.omtm.2020.02.003

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