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Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats

The aim of the research was to study formation of thymic lymphocytes proliferative response to T cell mitogen Concanavalin A in 7, 42, and 70 days-old male Wistar rats developmentally exposed to low doses of endocrine disruptor dichlorodiphenyltrichloroethane (2.90 ± 0.13 μg/kg body weight). The thy...

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Autores principales: Yaglova, Nataliya V., Tsomartova, Elina S., Obernikhin, Sergey S., Ivanova, Marina Y., Chereshneva, Elizaveta V., Muhamedova, Svetlana G., Lomanovskaya, Tatiana A., Yaglov, Valentin V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078513/
https://www.ncbi.nlm.nih.gov/pubmed/32195406
http://dx.doi.org/10.1016/j.heliyon.2020.e03608
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author Yaglova, Nataliya V.
Tsomartova, Elina S.
Obernikhin, Sergey S.
Ivanova, Marina Y.
Chereshneva, Elizaveta V.
Muhamedova, Svetlana G.
Lomanovskaya, Tatiana A.
Yaglov, Valentin V.
author_facet Yaglova, Nataliya V.
Tsomartova, Elina S.
Obernikhin, Sergey S.
Ivanova, Marina Y.
Chereshneva, Elizaveta V.
Muhamedova, Svetlana G.
Lomanovskaya, Tatiana A.
Yaglov, Valentin V.
author_sort Yaglova, Nataliya V.
collection PubMed
description The aim of the research was to study formation of thymic lymphocytes proliferative response to T cell mitogen Concanavalin A in 7, 42, and 70 days-old male Wistar rats developmentally exposed to low doses of endocrine disruptor dichlorodiphenyltrichloroethane (2.90 ± 0.13 μg/kg body weight). The thymus of the exposed rats did not show morphological abnormalities. Exposure to the endocrine disrupter was found to alter age-dependent changes of thymic lymphocyte proliferative activity and attenuate proliferative response to Concanavalin A in puberty and adulthood. Insufficient response to mitogen was mediated by higher content of actively proliferating Ki-67-positive lymphoblasts compared to the control values. Insufficient proliferative response to mitogen in developmentally exposed to the endocrine disruptor rats may provide higher risk of impaired cellular immune reactions.
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spelling pubmed-70785132020-03-19 Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats Yaglova, Nataliya V. Tsomartova, Elina S. Obernikhin, Sergey S. Ivanova, Marina Y. Chereshneva, Elizaveta V. Muhamedova, Svetlana G. Lomanovskaya, Tatiana A. Yaglov, Valentin V. Heliyon Article The aim of the research was to study formation of thymic lymphocytes proliferative response to T cell mitogen Concanavalin A in 7, 42, and 70 days-old male Wistar rats developmentally exposed to low doses of endocrine disruptor dichlorodiphenyltrichloroethane (2.90 ± 0.13 μg/kg body weight). The thymus of the exposed rats did not show morphological abnormalities. Exposure to the endocrine disrupter was found to alter age-dependent changes of thymic lymphocyte proliferative activity and attenuate proliferative response to Concanavalin A in puberty and adulthood. Insufficient response to mitogen was mediated by higher content of actively proliferating Ki-67-positive lymphoblasts compared to the control values. Insufficient proliferative response to mitogen in developmentally exposed to the endocrine disruptor rats may provide higher risk of impaired cellular immune reactions. Elsevier 2020-03-17 /pmc/articles/PMC7078513/ /pubmed/32195406 http://dx.doi.org/10.1016/j.heliyon.2020.e03608 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yaglova, Nataliya V.
Tsomartova, Elina S.
Obernikhin, Sergey S.
Ivanova, Marina Y.
Chereshneva, Elizaveta V.
Muhamedova, Svetlana G.
Lomanovskaya, Tatiana A.
Yaglov, Valentin V.
Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats
title Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats
title_full Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats
title_fullStr Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats
title_full_unstemmed Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats
title_short Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats
title_sort developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to concanavalin a in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078513/
https://www.ncbi.nlm.nih.gov/pubmed/32195406
http://dx.doi.org/10.1016/j.heliyon.2020.e03608
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