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Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats
The aim of the research was to study formation of thymic lymphocytes proliferative response to T cell mitogen Concanavalin A in 7, 42, and 70 days-old male Wistar rats developmentally exposed to low doses of endocrine disruptor dichlorodiphenyltrichloroethane (2.90 ± 0.13 μg/kg body weight). The thy...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078513/ https://www.ncbi.nlm.nih.gov/pubmed/32195406 http://dx.doi.org/10.1016/j.heliyon.2020.e03608 |
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author | Yaglova, Nataliya V. Tsomartova, Elina S. Obernikhin, Sergey S. Ivanova, Marina Y. Chereshneva, Elizaveta V. Muhamedova, Svetlana G. Lomanovskaya, Tatiana A. Yaglov, Valentin V. |
author_facet | Yaglova, Nataliya V. Tsomartova, Elina S. Obernikhin, Sergey S. Ivanova, Marina Y. Chereshneva, Elizaveta V. Muhamedova, Svetlana G. Lomanovskaya, Tatiana A. Yaglov, Valentin V. |
author_sort | Yaglova, Nataliya V. |
collection | PubMed |
description | The aim of the research was to study formation of thymic lymphocytes proliferative response to T cell mitogen Concanavalin A in 7, 42, and 70 days-old male Wistar rats developmentally exposed to low doses of endocrine disruptor dichlorodiphenyltrichloroethane (2.90 ± 0.13 μg/kg body weight). The thymus of the exposed rats did not show morphological abnormalities. Exposure to the endocrine disrupter was found to alter age-dependent changes of thymic lymphocyte proliferative activity and attenuate proliferative response to Concanavalin A in puberty and adulthood. Insufficient response to mitogen was mediated by higher content of actively proliferating Ki-67-positive lymphoblasts compared to the control values. Insufficient proliferative response to mitogen in developmentally exposed to the endocrine disruptor rats may provide higher risk of impaired cellular immune reactions. |
format | Online Article Text |
id | pubmed-7078513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-70785132020-03-19 Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats Yaglova, Nataliya V. Tsomartova, Elina S. Obernikhin, Sergey S. Ivanova, Marina Y. Chereshneva, Elizaveta V. Muhamedova, Svetlana G. Lomanovskaya, Tatiana A. Yaglov, Valentin V. Heliyon Article The aim of the research was to study formation of thymic lymphocytes proliferative response to T cell mitogen Concanavalin A in 7, 42, and 70 days-old male Wistar rats developmentally exposed to low doses of endocrine disruptor dichlorodiphenyltrichloroethane (2.90 ± 0.13 μg/kg body weight). The thymus of the exposed rats did not show morphological abnormalities. Exposure to the endocrine disrupter was found to alter age-dependent changes of thymic lymphocyte proliferative activity and attenuate proliferative response to Concanavalin A in puberty and adulthood. Insufficient response to mitogen was mediated by higher content of actively proliferating Ki-67-positive lymphoblasts compared to the control values. Insufficient proliferative response to mitogen in developmentally exposed to the endocrine disruptor rats may provide higher risk of impaired cellular immune reactions. Elsevier 2020-03-17 /pmc/articles/PMC7078513/ /pubmed/32195406 http://dx.doi.org/10.1016/j.heliyon.2020.e03608 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yaglova, Nataliya V. Tsomartova, Elina S. Obernikhin, Sergey S. Ivanova, Marina Y. Chereshneva, Elizaveta V. Muhamedova, Svetlana G. Lomanovskaya, Tatiana A. Yaglov, Valentin V. Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats |
title | Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats |
title_full | Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats |
title_fullStr | Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats |
title_full_unstemmed | Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats |
title_short | Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats |
title_sort | developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to concanavalin a in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078513/ https://www.ncbi.nlm.nih.gov/pubmed/32195406 http://dx.doi.org/10.1016/j.heliyon.2020.e03608 |
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