Disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of Salmonella Kottbus in Germany, 2017

In June 2017, an outbreak of Salmonella Kottbus infection was suspected in Germany. We investigated the outbreak with whole-genome sequencing (WGS) and a case–control study. Forty-six isolates from 69 cases were subtyped. Three WGS clusters were identified: cluster 1 (n = 36), cluster 2 (n = 5) and...

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Autores principales: Enkelmann, J., von Laer, A., Simon, S., Fruth, A., Lachmann, R., Michaelis, K., Borowiak, M., Gillesberg Lassen, S., Frank, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078581/
https://www.ncbi.nlm.nih.gov/pubmed/32052718
http://dx.doi.org/10.1017/S0950268820000394
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author Enkelmann, J.
von Laer, A.
Simon, S.
Fruth, A.
Lachmann, R.
Michaelis, K.
Borowiak, M.
Gillesberg Lassen, S.
Frank, C.
author_facet Enkelmann, J.
von Laer, A.
Simon, S.
Fruth, A.
Lachmann, R.
Michaelis, K.
Borowiak, M.
Gillesberg Lassen, S.
Frank, C.
author_sort Enkelmann, J.
collection PubMed
description In June 2017, an outbreak of Salmonella Kottbus infection was suspected in Germany. We investigated the outbreak with whole-genome sequencing (WGS) and a case–control study. Forty-six isolates from 69 cases were subtyped. Three WGS clusters were identified: cluster 1 (n = 36), cluster 2 (n = 5) and cluster 3 (n = 3). Compared to controls, cluster 1 cases more frequently consumed raw smoked ham (odds ratio (OR) 10, 95% confidence interval (CI) 1.2–88) bought at supermarket chain X (OR 36, 95% CI 4–356; 9/10 consumed ham Y). All four cluster 2 cases interviewed had consumed quail eggs. Timely WGS was invaluable in distinguishing concurrent outbreaks of a rare Salmonella serotype.
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spelling pubmed-70785812020-03-23 Disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of Salmonella Kottbus in Germany, 2017 Enkelmann, J. von Laer, A. Simon, S. Fruth, A. Lachmann, R. Michaelis, K. Borowiak, M. Gillesberg Lassen, S. Frank, C. Epidemiol Infect Original Paper In June 2017, an outbreak of Salmonella Kottbus infection was suspected in Germany. We investigated the outbreak with whole-genome sequencing (WGS) and a case–control study. Forty-six isolates from 69 cases were subtyped. Three WGS clusters were identified: cluster 1 (n = 36), cluster 2 (n = 5) and cluster 3 (n = 3). Compared to controls, cluster 1 cases more frequently consumed raw smoked ham (odds ratio (OR) 10, 95% confidence interval (CI) 1.2–88) bought at supermarket chain X (OR 36, 95% CI 4–356; 9/10 consumed ham Y). All four cluster 2 cases interviewed had consumed quail eggs. Timely WGS was invaluable in distinguishing concurrent outbreaks of a rare Salmonella serotype. Cambridge University Press 2020-02-13 /pmc/articles/PMC7078581/ /pubmed/32052718 http://dx.doi.org/10.1017/S0950268820000394 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Enkelmann, J.
von Laer, A.
Simon, S.
Fruth, A.
Lachmann, R.
Michaelis, K.
Borowiak, M.
Gillesberg Lassen, S.
Frank, C.
Disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of Salmonella Kottbus in Germany, 2017
title Disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of Salmonella Kottbus in Germany, 2017
title_full Disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of Salmonella Kottbus in Germany, 2017
title_fullStr Disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of Salmonella Kottbus in Germany, 2017
title_full_unstemmed Disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of Salmonella Kottbus in Germany, 2017
title_short Disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of Salmonella Kottbus in Germany, 2017
title_sort disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of salmonella kottbus in germany, 2017
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078581/
https://www.ncbi.nlm.nih.gov/pubmed/32052718
http://dx.doi.org/10.1017/S0950268820000394
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