Patient with frontal-variant syndrome in early-onset Alzheimer's disease

The clinical manifestation of frontal-variant Alzheimer’s disease (fvAD) is not typical, and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia (fvFTD). We describe a patient with early-onset Alzheimer’s disease (AD) who presented with an fvFTD-like sy...

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Autores principales: Cai, Han, Ning, Su, Li, Wei, Li, Xia, Xiao, Shifu, Sun, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078674/
https://www.ncbi.nlm.nih.gov/pubmed/32215362
http://dx.doi.org/10.1136/gpsych-2019-100173
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author Cai, Han
Ning, Su
Li, Wei
Li, Xia
Xiao, Shifu
Sun, Lin
author_facet Cai, Han
Ning, Su
Li, Wei
Li, Xia
Xiao, Shifu
Sun, Lin
author_sort Cai, Han
collection PubMed
description The clinical manifestation of frontal-variant Alzheimer’s disease (fvAD) is not typical, and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia (fvFTD). We describe a patient with early-onset Alzheimer’s disease (AD) who presented with an fvFTD-like syndrome and apolipoprotein E ɛ3/ ɛ4 genotype. A brain amyloid imaging procedure, 11C-Pittsburgh compound B positron emission tomography (PET), supported the final diagnosis of AD. Our present case highlights the clinical variability that characterises early-onset AD. A multimodal approach is crucial when assessing rare forms of dementia.
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spelling pubmed-70786742020-03-25 Patient with frontal-variant syndrome in early-onset Alzheimer's disease Cai, Han Ning, Su Li, Wei Li, Xia Xiao, Shifu Sun, Lin Gen Psychiatr Case Report The clinical manifestation of frontal-variant Alzheimer’s disease (fvAD) is not typical, and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia (fvFTD). We describe a patient with early-onset Alzheimer’s disease (AD) who presented with an fvFTD-like syndrome and apolipoprotein E ɛ3/ ɛ4 genotype. A brain amyloid imaging procedure, 11C-Pittsburgh compound B positron emission tomography (PET), supported the final diagnosis of AD. Our present case highlights the clinical variability that characterises early-onset AD. A multimodal approach is crucial when assessing rare forms of dementia. BMJ Publishing Group 2020-03-17 /pmc/articles/PMC7078674/ /pubmed/32215362 http://dx.doi.org/10.1136/gpsych-2019-100173 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Case Report
Cai, Han
Ning, Su
Li, Wei
Li, Xia
Xiao, Shifu
Sun, Lin
Patient with frontal-variant syndrome in early-onset Alzheimer's disease
title Patient with frontal-variant syndrome in early-onset Alzheimer's disease
title_full Patient with frontal-variant syndrome in early-onset Alzheimer's disease
title_fullStr Patient with frontal-variant syndrome in early-onset Alzheimer's disease
title_full_unstemmed Patient with frontal-variant syndrome in early-onset Alzheimer's disease
title_short Patient with frontal-variant syndrome in early-onset Alzheimer's disease
title_sort patient with frontal-variant syndrome in early-onset alzheimer's disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078674/
https://www.ncbi.nlm.nih.gov/pubmed/32215362
http://dx.doi.org/10.1136/gpsych-2019-100173
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