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Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain

The caudate nucleus (CN) and the putamen (PUT) as parts of the human striatum are distinguished by a marked heterogeneity in functional, anatomical, and neurochemical patterns. Our study aimed to document in detail the regional diversity in the distribution of dopamine (DA), serotonin, γ‐aminobuturi...

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Autores principales: Hörtnagl, Heide, Pifl, Christian, Hörtnagl, Erik, Reiner, Angelika, Sperk, Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078952/
https://www.ncbi.nlm.nih.gov/pubmed/31608979
http://dx.doi.org/10.1111/jnc.14897
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author Hörtnagl, Heide
Pifl, Christian
Hörtnagl, Erik
Reiner, Angelika
Sperk, Günther
author_facet Hörtnagl, Heide
Pifl, Christian
Hörtnagl, Erik
Reiner, Angelika
Sperk, Günther
author_sort Hörtnagl, Heide
collection PubMed
description The caudate nucleus (CN) and the putamen (PUT) as parts of the human striatum are distinguished by a marked heterogeneity in functional, anatomical, and neurochemical patterns. Our study aimed to document in detail the regional diversity in the distribution of dopamine (DA), serotonin, γ‐aminobuturic acid, and choline acetyltransferase within the CN and PUT. For this purpose we dissected the CN as well as the PUT of 12 post‐mortem brains of human subjects with no evidence of neurological and psychiatric disorders (38–81 years old) into about 80 tissue parts. We then investigated rostro‐caudal, dorso‐ventral, and medio‐lateral gradients of these neurotransmitter markers. All parameters revealed higher levels, turnover rates, or activities in the PUT than in the CN. Within the PUT, DA levels increased continuously from rostral to caudal. In contrast, the lowest molar ratio of homovanillic acid to DA, a marker of DA turnover, coincided with highest DA levels in the caudal PUT, the part of the striatum with the highest loss of DA in Parkinson’s disease (N. Engl. J. Med., 318, 1988, 876). Highest DA concentrations were found in the most central areas both in the PUT and CN. We observed an age‐dependent loss of DA in the PUT and CN that did not correspond to the loss described for Parkinson’s disease indicating different mechanisms inducing the deficit of DA. Our data demonstrate a marked heterogeneity in the anatomical distribution of neurotransmitter markers in the human dorsal striatum indicating anatomical and functional diversity within this brain structure. [Image: see text]
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spelling pubmed-70789522020-03-19 Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain Hörtnagl, Heide Pifl, Christian Hörtnagl, Erik Reiner, Angelika Sperk, Günther J Neurochem ORIGINAL ARTICLES The caudate nucleus (CN) and the putamen (PUT) as parts of the human striatum are distinguished by a marked heterogeneity in functional, anatomical, and neurochemical patterns. Our study aimed to document in detail the regional diversity in the distribution of dopamine (DA), serotonin, γ‐aminobuturic acid, and choline acetyltransferase within the CN and PUT. For this purpose we dissected the CN as well as the PUT of 12 post‐mortem brains of human subjects with no evidence of neurological and psychiatric disorders (38–81 years old) into about 80 tissue parts. We then investigated rostro‐caudal, dorso‐ventral, and medio‐lateral gradients of these neurotransmitter markers. All parameters revealed higher levels, turnover rates, or activities in the PUT than in the CN. Within the PUT, DA levels increased continuously from rostral to caudal. In contrast, the lowest molar ratio of homovanillic acid to DA, a marker of DA turnover, coincided with highest DA levels in the caudal PUT, the part of the striatum with the highest loss of DA in Parkinson’s disease (N. Engl. J. Med., 318, 1988, 876). Highest DA concentrations were found in the most central areas both in the PUT and CN. We observed an age‐dependent loss of DA in the PUT and CN that did not correspond to the loss described for Parkinson’s disease indicating different mechanisms inducing the deficit of DA. Our data demonstrate a marked heterogeneity in the anatomical distribution of neurotransmitter markers in the human dorsal striatum indicating anatomical and functional diversity within this brain structure. [Image: see text] John Wiley and Sons Inc. 2019-11-28 2020-03 /pmc/articles/PMC7078952/ /pubmed/31608979 http://dx.doi.org/10.1111/jnc.14897 Text en © 2019 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle ORIGINAL ARTICLES
Hörtnagl, Heide
Pifl, Christian
Hörtnagl, Erik
Reiner, Angelika
Sperk, Günther
Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain
title Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain
title_full Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain
title_fullStr Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain
title_full_unstemmed Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain
title_short Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain
title_sort distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078952/
https://www.ncbi.nlm.nih.gov/pubmed/31608979
http://dx.doi.org/10.1111/jnc.14897
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