NHC‐Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines

The preparation of N‐heterocyclic carbene‐stabilized iridium nanoparticles and their application in hydrogen isotope exchange reactions is reported. These air‐stable and easy‐to‐handle iridium nanoparticles showed a unique catalytic activity, allowing selective and efficient hydrogen isotope incorpo...

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Detalles Bibliográficos
Autores principales: Valero, Mégane, Bouzouita, Donia, Palazzolo, Alberto, Atzrodt, Jens, Dugave, Christophe, Tricard, Simon, Feuillastre, Sophie, Pieters, Grégory, Chaudret, Bruno, Derdau, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079112/
https://www.ncbi.nlm.nih.gov/pubmed/31849160
http://dx.doi.org/10.1002/anie.201914369
Descripción
Sumario:The preparation of N‐heterocyclic carbene‐stabilized iridium nanoparticles and their application in hydrogen isotope exchange reactions is reported. These air‐stable and easy‐to‐handle iridium nanoparticles showed a unique catalytic activity, allowing selective and efficient hydrogen isotope incorporation on anilines using D(2) or T(2) as isotopic source. The usefulness of this transformation has been demonstrated by the deuterium and tritium labeling of diverse complex pharmaceuticals.

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