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(11)C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α‐Synuclein Fibrils in vitro and Crosses the Blood‐Brain Barrier

There is an urgent clinical need for imaging of α‐synuclein (αSyn) fibrils, the hallmark biomarker for Parkinson's disease, in neurodegenerative disorders. Despite immense efforts, promising tracer candidates for nuclear imaging of αSyn are rare. Diphenyl pyrazoles are known modulators of αSyn...

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Detalles Bibliográficos
Autores principales:	Maurer, Andreas, Leonov, Andrei, Ryazanov, Sergey, Herfert, Kristina, Kuebler, Laura, Buss, Sabrina, Schmidt, Felix, Weckbecker, Daniel, Linder, Ruth, Bender, Dirk, Giese, Armin, Pichler, Bernd J., Griesinger, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079211/ https://www.ncbi.nlm.nih.gov/pubmed/31859430 http://dx.doi.org/10.1002/cmdc.201900689

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