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Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis

BACKGROUND: Emerging studies have explored the association between the famine exposure during early life and the risk of the metabolic syndrome, and the results remain controversial. This meta-analysis was performed to summarize the famine effects on the prevalence of metabolic syndrome (MetS) in ad...

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Autores principales: Qin, Lu-Lu, Luo, Bang-An, Gao, Fan, Feng, Xiang-Lin, Liu, Jia-He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079216/
https://www.ncbi.nlm.nih.gov/pubmed/32258164
http://dx.doi.org/10.1155/2020/3251275
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author Qin, Lu-Lu
Luo, Bang-An
Gao, Fan
Feng, Xiang-Lin
Liu, Jia-He
author_facet Qin, Lu-Lu
Luo, Bang-An
Gao, Fan
Feng, Xiang-Lin
Liu, Jia-He
author_sort Qin, Lu-Lu
collection PubMed
description BACKGROUND: Emerging studies have explored the association between the famine exposure during early life and the risk of the metabolic syndrome, and the results remain controversial. This meta-analysis was performed to summarize the famine effects on the prevalence of metabolic syndrome (MetS) in adulthood. Materials and Methods. We searched the PubMed, Web of Science, Embase, ScienceDirect, and Chinese National Knowledge Infrastructure for relevant studies up to December 2019. Pooled odd ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the effect exposure to famine on MetS using a random-effects model, and the I(2) was used to evaluate the heterogeneity. RESULTS: The analyses included 39 studies from 10 articles with a total of 81504 participants. Fourteen studies from 10 articles for fetal famine exposure, 20 studies from 7 articles for childhood famine exposure, and 5 studies from 3 articles for adolescence/adult famine exposure were included in this meta-analysis. Compared with a nonexposed group, famine exposure significantly increased the risk of MetS for early life famine exposure (OR = 1.27, 95% CI: 1.18-1.38), fetal famine exposure (OR = 1.27, 95% CI: 1.14-1.43), and childhood famine exposure (OR = 1.29, 95% CI: 1.16-1.44). Subgroup analyses showed that the result was consistent regardless of the study designs, definitions of MetS, and causes of famine, with or without adjustment for age, smoking, drinking, and physical activity. CONCLUSIONS: This meta-analysis suggests that exposure to famine during early life may increase the risk of MetS in adulthood.
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spelling pubmed-70792162020-04-03 Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis Qin, Lu-Lu Luo, Bang-An Gao, Fan Feng, Xiang-Lin Liu, Jia-He J Diabetes Res Review Article BACKGROUND: Emerging studies have explored the association between the famine exposure during early life and the risk of the metabolic syndrome, and the results remain controversial. This meta-analysis was performed to summarize the famine effects on the prevalence of metabolic syndrome (MetS) in adulthood. Materials and Methods. We searched the PubMed, Web of Science, Embase, ScienceDirect, and Chinese National Knowledge Infrastructure for relevant studies up to December 2019. Pooled odd ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the effect exposure to famine on MetS using a random-effects model, and the I(2) was used to evaluate the heterogeneity. RESULTS: The analyses included 39 studies from 10 articles with a total of 81504 participants. Fourteen studies from 10 articles for fetal famine exposure, 20 studies from 7 articles for childhood famine exposure, and 5 studies from 3 articles for adolescence/adult famine exposure were included in this meta-analysis. Compared with a nonexposed group, famine exposure significantly increased the risk of MetS for early life famine exposure (OR = 1.27, 95% CI: 1.18-1.38), fetal famine exposure (OR = 1.27, 95% CI: 1.14-1.43), and childhood famine exposure (OR = 1.29, 95% CI: 1.16-1.44). Subgroup analyses showed that the result was consistent regardless of the study designs, definitions of MetS, and causes of famine, with or without adjustment for age, smoking, drinking, and physical activity. CONCLUSIONS: This meta-analysis suggests that exposure to famine during early life may increase the risk of MetS in adulthood. Hindawi 2020-03-05 /pmc/articles/PMC7079216/ /pubmed/32258164 http://dx.doi.org/10.1155/2020/3251275 Text en Copyright © 2020 Lu-Lu Qin et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Qin, Lu-Lu
Luo, Bang-An
Gao, Fan
Feng, Xiang-Lin
Liu, Jia-He
Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis
title Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis
title_full Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis
title_fullStr Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis
title_full_unstemmed Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis
title_short Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis
title_sort effect of exposure to famine during early life on risk of metabolic syndrome in adulthood: a meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079216/
https://www.ncbi.nlm.nih.gov/pubmed/32258164
http://dx.doi.org/10.1155/2020/3251275
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