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Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells

BACKGROUND: Glial cell line-derived neurotrophic factor (GDNF) is highly expressed in glioblastoma (GBM) and blocking its expression can inhibit the initiation and development of GBM. GDNF is a dual promoter gene, and the promoter II with two enhancers and two silencers plays a major role in transcr...

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Detalles Bibliográficos
Autores principales: Zhang, Baole, Gu, Xiaohe, Han, Xiao, Gao, Qing, Liu, Jie, Guo, Tingwen, Gao, Dianshuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079383/
https://www.ncbi.nlm.nih.gov/pubmed/32183903
http://dx.doi.org/10.1186/s13148-020-00835-3

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