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Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells
BACKGROUND: Glial cell line-derived neurotrophic factor (GDNF) is highly expressed in glioblastoma (GBM) and blocking its expression can inhibit the initiation and development of GBM. GDNF is a dual promoter gene, and the promoter II with two enhancers and two silencers plays a major role in transcr...
Autores principales: | Zhang, Baole, Gu, Xiaohe, Han, Xiao, Gao, Qing, Liu, Jie, Guo, Tingwen, Gao, Dianshuai |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079383/ https://www.ncbi.nlm.nih.gov/pubmed/32183903 http://dx.doi.org/10.1186/s13148-020-00835-3 |
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