Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients

BACKGROUND: Acute respiratory distress syndrome continues to drive significant morbidity and mortality after severe trauma. The incidence of trauma-induced, moderate-to-severe hypoxaemia, according to the Berlin definition, could be as high as 45%. Its pathophysiology includes the release of damage-...

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Detalles Bibliográficos
Autores principales: Pottecher, Julien, Noll, Eric, Borel, Marie, Audibert, Gérard, Gette, Sébastien, Meyer, Christian, Gaertner, Elisabeth, Legros, Vincent, Carapito, Raphaël, Uring-Lambert, Béatrice, Sauleau, Erik, Land, Walter G., Bahram, Seiamak, Meyer, Alain, Geny, Bernard, Diemunsch, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079402/
https://www.ncbi.nlm.nih.gov/pubmed/32183886
http://dx.doi.org/10.1186/s13063-020-4141-6

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