Cargando…
Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial
BACKGROUND: As a lifetime disorder, ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that affects quality of life and also demands long-term interventions. In spite of considerable side effects and sometimes restricted uses, efficient medications are available for UC treatment. Some in...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079449/ https://www.ncbi.nlm.nih.gov/pubmed/32183895 http://dx.doi.org/10.1186/s13063-020-4193-7 |
_version_ | 1783507826262409216 |
---|---|
author | Shayesteh, Forough Haidari, Fatemeh Shayesteh, Ali Akbar Mohammadi-Asl, Javad Ahmadi-Angali, Kambiz |
author_facet | Shayesteh, Forough Haidari, Fatemeh Shayesteh, Ali Akbar Mohammadi-Asl, Javad Ahmadi-Angali, Kambiz |
author_sort | Shayesteh, Forough |
collection | PubMed |
description | BACKGROUND: As a lifetime disorder, ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that affects quality of life and also demands long-term interventions. In spite of considerable side effects and sometimes restricted uses, efficient medications are available for UC treatment. Some in vitro and in vivo examinations have correspondingly introduced ginger and its active components with antioxidant, anti-inflammatory, and anti-ulcerative properties. Therefore, this trial aims to evaluate the effect of ginger supplementation on patients with active UC. METHODS: This study will be a 12-week, double-blind, parallel-group, randomized, controlled trial (RCT) in which 44 patients will be allocated to ginger and placebo groups receiving basic routine treatments plus ginger or placebo capsules, respectively. The primary outcomes are inflammatory markers (TNF-α and hs-CRP) and total antioxidant capacity. DISCUSSION: The findings of this trial will provide evidence on the effect of ginger on patients with active UC. TRIAL REGISTRATION: Iranian Registry of Clinical Trials, IRCT20190129042552N1. Registered on 21 June 2019. |
format | Online Article Text |
id | pubmed-7079449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70794492020-03-23 Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial Shayesteh, Forough Haidari, Fatemeh Shayesteh, Ali Akbar Mohammadi-Asl, Javad Ahmadi-Angali, Kambiz Trials Study Protocol BACKGROUND: As a lifetime disorder, ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that affects quality of life and also demands long-term interventions. In spite of considerable side effects and sometimes restricted uses, efficient medications are available for UC treatment. Some in vitro and in vivo examinations have correspondingly introduced ginger and its active components with antioxidant, anti-inflammatory, and anti-ulcerative properties. Therefore, this trial aims to evaluate the effect of ginger supplementation on patients with active UC. METHODS: This study will be a 12-week, double-blind, parallel-group, randomized, controlled trial (RCT) in which 44 patients will be allocated to ginger and placebo groups receiving basic routine treatments plus ginger or placebo capsules, respectively. The primary outcomes are inflammatory markers (TNF-α and hs-CRP) and total antioxidant capacity. DISCUSSION: The findings of this trial will provide evidence on the effect of ginger on patients with active UC. TRIAL REGISTRATION: Iranian Registry of Clinical Trials, IRCT20190129042552N1. Registered on 21 June 2019. BioMed Central 2020-03-18 /pmc/articles/PMC7079449/ /pubmed/32183895 http://dx.doi.org/10.1186/s13063-020-4193-7 Text en © The Author(s). 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Study Protocol Shayesteh, Forough Haidari, Fatemeh Shayesteh, Ali Akbar Mohammadi-Asl, Javad Ahmadi-Angali, Kambiz Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial |
title | Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial |
title_full | Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial |
title_fullStr | Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial |
title_full_unstemmed | Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial |
title_short | Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial |
title_sort | ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079449/ https://www.ncbi.nlm.nih.gov/pubmed/32183895 http://dx.doi.org/10.1186/s13063-020-4193-7 |
work_keys_str_mv | AT shayestehforough gingerinpatientswithactiveulcerativecolitisastudyprotocolforarandomizedcontrolledtrial AT haidarifatemeh gingerinpatientswithactiveulcerativecolitisastudyprotocolforarandomizedcontrolledtrial AT shayestehaliakbar gingerinpatientswithactiveulcerativecolitisastudyprotocolforarandomizedcontrolledtrial AT mohammadiasljavad gingerinpatientswithactiveulcerativecolitisastudyprotocolforarandomizedcontrolledtrial AT ahmadiangalikambiz gingerinpatientswithactiveulcerativecolitisastudyprotocolforarandomizedcontrolledtrial |