Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions

Human prion diseases are characterized by the accumulation in the brain of proteinase K (PK)-resistant prion protein designated PrP27-30 detectable by the 3F4 antibody against human PrP109-112. We recently identified a new PK-resistant PrP species, designated PrP(*20), in uninfected human and animal...

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Detalles Bibliográficos
Autores principales: Yuan, J., Dong, Z., Guo, J.-P., McGeehan, J., Xiao, X., Wang, J., Cali, I., McGeer, P. L., Cashman, N. R., Bessen, R., Surewicz, W. K., Kneale, G., Petersen, R. B., Gambetti, P., Zou, W. Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Birkhäuser-Verlag 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079802/
https://www.ncbi.nlm.nih.gov/pubmed/18193391
http://dx.doi.org/10.1007/s00018-007-7478-z

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