The role of lipocalin-2 in age-related macular degeneration (AMD)

Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obes...

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Detalles Bibliográficos
Autores principales: Ghosh, Sayan, Stepicheva, Nadezda, Yazdankhah, Meysam, Shang, Peng, Watson, Alan M., Hose, Stacey, Liu, Haitao, Weiss, Joseph, Zigler, J. Samuel, Valapala, Mallika, Watkins, Simon C., Sinha, Debasish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079812/
https://www.ncbi.nlm.nih.gov/pubmed/31901947
http://dx.doi.org/10.1007/s00018-019-03423-8
Descripción
Sumario:Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00018-019-03423-8) contains supplementary material, which is available to authorized users.

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