The role of lipocalin-2 in age-related macular degeneration (AMD)

Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obes...

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Autores principales: Ghosh, Sayan, Stepicheva, Nadezda, Yazdankhah, Meysam, Shang, Peng, Watson, Alan M., Hose, Stacey, Liu, Haitao, Weiss, Joseph, Zigler, J. Samuel, Valapala, Mallika, Watkins, Simon C., Sinha, Debasish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079812/
https://www.ncbi.nlm.nih.gov/pubmed/31901947
http://dx.doi.org/10.1007/s00018-019-03423-8
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author Ghosh, Sayan
Stepicheva, Nadezda
Yazdankhah, Meysam
Shang, Peng
Watson, Alan M.
Hose, Stacey
Liu, Haitao
Weiss, Joseph
Zigler, J. Samuel
Valapala, Mallika
Watkins, Simon C.
Sinha, Debasish
author_facet Ghosh, Sayan
Stepicheva, Nadezda
Yazdankhah, Meysam
Shang, Peng
Watson, Alan M.
Hose, Stacey
Liu, Haitao
Weiss, Joseph
Zigler, J. Samuel
Valapala, Mallika
Watkins, Simon C.
Sinha, Debasish
author_sort Ghosh, Sayan
collection PubMed
description Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00018-019-03423-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-70798122020-03-23 The role of lipocalin-2 in age-related macular degeneration (AMD) Ghosh, Sayan Stepicheva, Nadezda Yazdankhah, Meysam Shang, Peng Watson, Alan M. Hose, Stacey Liu, Haitao Weiss, Joseph Zigler, J. Samuel Valapala, Mallika Watkins, Simon C. Sinha, Debasish Cell Mol Life Sci Review Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00018-019-03423-8) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-01-04 2020 /pmc/articles/PMC7079812/ /pubmed/31901947 http://dx.doi.org/10.1007/s00018-019-03423-8 Text en © Springer Nature Switzerland AG 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Ghosh, Sayan
Stepicheva, Nadezda
Yazdankhah, Meysam
Shang, Peng
Watson, Alan M.
Hose, Stacey
Liu, Haitao
Weiss, Joseph
Zigler, J. Samuel
Valapala, Mallika
Watkins, Simon C.
Sinha, Debasish
The role of lipocalin-2 in age-related macular degeneration (AMD)
title The role of lipocalin-2 in age-related macular degeneration (AMD)
title_full The role of lipocalin-2 in age-related macular degeneration (AMD)
title_fullStr The role of lipocalin-2 in age-related macular degeneration (AMD)
title_full_unstemmed The role of lipocalin-2 in age-related macular degeneration (AMD)
title_short The role of lipocalin-2 in age-related macular degeneration (AMD)
title_sort role of lipocalin-2 in age-related macular degeneration (amd)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079812/
https://www.ncbi.nlm.nih.gov/pubmed/31901947
http://dx.doi.org/10.1007/s00018-019-03423-8
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