Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus

To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression we...

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Detalles Bibliográficos
Autores principales: Cinatl Jr., J., Hoever, G., Morgenstern, B., Preiser, W., Vogel, J.-U., Hofmann, W.-K., Bauer, G., Michaelis, M., Rabenau, H. F., Doerr, H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Birkhäuser-Verlag 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079841/
https://www.ncbi.nlm.nih.gov/pubmed/15316659
http://dx.doi.org/10.1007/s00018-004-4222-9
Descripción
Sumario:To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.

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