Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus

To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression we...

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Autores principales: Cinatl Jr., J., Hoever, G., Morgenstern, B., Preiser, W., Vogel, J.-U., Hofmann, W.-K., Bauer, G., Michaelis, M., Rabenau, H. F., Doerr, H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Birkhäuser-Verlag 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079841/
https://www.ncbi.nlm.nih.gov/pubmed/15316659
http://dx.doi.org/10.1007/s00018-004-4222-9
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author Cinatl Jr., J.
Hoever, G.
Morgenstern, B.
Preiser, W.
Vogel, J.-U.
Hofmann, W.-K.
Bauer, G.
Michaelis, M.
Rabenau, H. F.
Doerr, H. W.
author_facet Cinatl Jr., J.
Hoever, G.
Morgenstern, B.
Preiser, W.
Vogel, J.-U.
Hofmann, W.-K.
Bauer, G.
Michaelis, M.
Rabenau, H. F.
Doerr, H. W.
author_sort Cinatl Jr., J.
collection PubMed
description To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.
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spelling pubmed-70798412020-03-23 Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus Cinatl Jr., J. Hoever, G. Morgenstern, B. Preiser, W. Vogel, J.-U. Hofmann, W.-K. Bauer, G. Michaelis, M. Rabenau, H. F. Doerr, H. W. Cell Mol Life Sci Research Article To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS. Birkhäuser-Verlag 2004 /pmc/articles/PMC7079841/ /pubmed/15316659 http://dx.doi.org/10.1007/s00018-004-4222-9 Text en © Birkhäuser-Verlag Basel 2004 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Article
Cinatl Jr., J.
Hoever, G.
Morgenstern, B.
Preiser, W.
Vogel, J.-U.
Hofmann, W.-K.
Bauer, G.
Michaelis, M.
Rabenau, H. F.
Doerr, H. W.
Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
title Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
title_full Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
title_fullStr Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
title_full_unstemmed Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
title_short Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
title_sort infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079841/
https://www.ncbi.nlm.nih.gov/pubmed/15316659
http://dx.doi.org/10.1007/s00018-004-4222-9
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